Synonym:
(R)-(−)-MTPA-Cl,
Mosher’s acid chloride
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CAS Number 39637-99-5
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Linear Formula C6H5C(OCH3)(CF3)COCl
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Molecular Weight 252.62
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Beilstein Registry Number 3591568
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MDL number MFCD00044400
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PubChem Substance ID 329760054
Properties:
| Related Categories |
Analytical Reagents,
Analytical/Chromatography,
Chiral,
Chiral Derivatization Reagents,
Chiral GC Derivatization Reagents,
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grade
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for chiral derivatization
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InChI Key
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PAORVUMOXXAMPL-VIFPVBQESA-N
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assay
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≥99.0% (AT)
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≥99.0%
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optical activity
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[α]20/D −137±2°, c = 6.4% in carbon tetrachloride
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optical purity
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enantiomeric ratio: ≥99.5:0.5 (GC)
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refractive index
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n20/D 1.469
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n20/D 1.47(lit.)
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bp
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213-214 °C(lit.)
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density
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1.35 g/mL at 25 °C(lit.)
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shipped in
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wet ice
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storage temp.
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−20°C
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Description:
Other Notes
Please note that R(-)-MTPA-Cl is derived from S(-)-MTPA
Packaging
100, 500 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.
Application
It was used for derivatizing D-arabinitol and L-arabinitol samples for high performance thin layer chromatography (HPTLC) analysis for studying resolution of the diastereoisomer.
Ready-to-use reagent for the determination of the enantiomeric purity of alcohols and amines after derivatization; doi:10.1038/nprot.2007.354
General description
(R)-(-)-a-Methoxy-a-(trifluoromethyl)phenylacetyl chloride (Mosher’s acid chloride) is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.
Recommended products
Discover LiChropur reagents ideal for HPLC or LC-MS analysis
Safety:
Symbol

GHS05
Precautionary statements
P280-P305 + P351 + P338-P310
Personal Protective Equipment
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter