Synonym:
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride,
AEBSF
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CAS Number 30827-99-7
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Empirical Formula (Hill Notation) C8H10FNO2S · HCl
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Molecular Weight 239.69
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Beilstein Registry Number 7604627
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MDL number MFCD00132962
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PubChem Substance ID 329767025
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Popular Documents: Datasheet (PDF) | Specification Sheet (PDF)
Properties:
| Related Categories |
Additional Standards,
Aliphatics,
Amines,
Analytical Standards,
Analytical/Chromatography,
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grade
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analytical standard
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InChI Key
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WRDABNWSWOHGMS-UHFFFAOYSA-N
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assay
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≥97% (HPLC)
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form
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neat
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application(s)
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HPLC: suitable
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gas chromatography (GC): suitable
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mp
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~183 °C
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format
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neat
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storage temp.
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2-8°C
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Description:
Application
Recommended concentrations for use are 0.1-1 mM.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM.
Other Notes
Potent and irreversible inhibitor of serine proteases; in contrast to PMSF, it is water soluble and non-toxic; Unaffected by albumin
Legal Information
Pefabloc is a registered trademark of Pentapharm
Safety:
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RIDADR
NONH for all modes of transport