Sigma-Aldrich/Alprazolam/A8800-10MG/10MG

• CAS Number 28981-97-7

• Empirical Formula (Hill Notation) C₁₇H₁₃ClN₄

• Molecular Weight 308.76

•  EC Number 249-349-2

•  MDL number MFCD00078881

•  PubChem Substance ID 24891366

• Popular Documents:  Datasheet (PDF)  |  Specification Sheet (PDF)  

Properties:

Description:

Biochem/physiol Actions

Alprazolam binds the GABA_A receptor at the benzodiazepine site, which is different than the ligand-binding site at which GABA binds. Alprazolam has been shown to be an anxiolytic (anti-anxiety agent) as well as having anticonvulsant, muscle relaxant and antidepressant activity.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Alprazolam is a triazole-containing benzodiazepine that is related to diazepam and other 1,4-benxodiazepines. Like other benzodiazepines, Alprazolam is a GABAergic agonist that modulates GABA_A receptors. GABA_A receptors in the central nervous system are ligand-gated ion channels that are bound by the stimulatory neurotransmitter GABA; binding of this ligand allows ion movement through the channel and results in neurotransmission inhibition.

Safety:

Symbol 

  GHS07