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Millipore/AB10020 | Anti-acetyl-Histone H2A.X (Lys5) Antibody/AB10020/100 µg

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貨號: AB10020

品牌: Millipore

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Description
CatalogueNumber	AB10020
Description	Anti-acetyl-HistoneH2A.X(Lys5)Antibody
AlternateNames	H2AXK5Ac HistoneH2AX(acetylK5) H2Ahistonefamily,memberX H2AXhistone
BackgroundInformation	H2A.XisinvolvedinDNArepairandthemaintenanceofgenomicstABIlity,althoughitspreciseroleisstilltobedefined.H2AXisphosphorylatedsoonaftertheappearanceofdouble-strandedbreaksandhasbeenimplicatedbothinhomologousrecombinationandnonhomologousendjoiningDNArepairpathways.H2AXisthoughttohaveacriticalfunctionintherecruitmentofDNArepairfactorsandDNAdamage-signalingproteins.HyperphoshorylationofH2AXmaybelinkedtochromatinfragmentationpriortoapoptosis.

ProductInformation
Format	AffinityPurified
Control	SodiumbutyrateuntreatedandtreatedHeLaacidextract
Presentation	PurifiedrabbitpolyclonalcontainingPBSwith0.10%ofsodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	Anti-acetyl-HistoneH2A.X(Lys5)AntibodyisaRabbitPolyclonalAntibodyfordetectionofacetyl-HistoneH2A.X(Lys5)alsoknownasH2AXK5Ac,HistoneH2AX(AcK5)&hasbeenvalidatedinWB&Mplex.
KeyApplications	WesternBlotting Multiplexing
ApplicationNotes	Luminex?Assay

BIOLOGicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingtohumanHistoneH2A.XacetylatedatLys5.
Epitope	Lys5
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	ThisantibodyrecognizesHistoneH2A.XacetylatedatLys5.
SpeciesReactivity	Human
SpeciesReactivityNote	Demonstratedtoreactwithhuman.Predictedtoreactwithrat,mouse,zebrafish,bovineandcaninebasedon100%sequencehomology.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_002096.1.
EntrezGeneSummary	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneencodesamemberofthehistoneH2Afamily,andgeneratestwotranscriptsthroughtheuseoftheconservedstem-loopterminationmotif,andthepolyAadditionmotif.
GeneSymbol	H2AFX H2A.X H2A/X H2AX H2a/x
Modifications	Acetylation
PurificationMethod	AffinityPurfied
UniProtNumber	P16104
UniProtSummary	FUNCTION:VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Requiredforcheckpoint-mediatedarrestofcellcycleprogressioninresponsetolowdosesofionizingrADIationandforefficientrepairofDNAdoublestrandbreaks(DSBs)specificallywhenmodifiedbyC-terminalphosphorylation. SIZE:143aminoacids;15145Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.InteractswithnumerousproteinsrequiredforDNAdamagesignalingandrepairwhenphosphorylatedonSer-140.TheseincludeMDC1,TP53BP1,BRCA1andtheMRNcomplex,composedofMRE11A,RAD50,andNBN.InteractionwiththeMRNcomplexismediatedatleastinpartbyNBN.AlsointeractswithDHX9/NDHIIwhenphosphorylatedonSer-140. SUBCELLULARLOCATION:Nucleus.DEVELOPMENTALSTAGE:SynthesizedinG1aswellasinS-phase. DOMAIN:The[ST]-QmotifconstitutesarecognitionsequenceforkinasesfromthePI3/PI4-kinasefamily. PTM:PhosphorylatedonSer-140(toformgamma-H2AFX)inresponsetoDNAdoublestrandbreaks(DSBs)generatedbyexogenousgenotoxicagentsandbystalledreplicationforks,andmayalsooccurduringmeioticrecombinationeventsandimmunoglobulinclassswitchinginlymphocytes.PhosphorylationcanextenduptoseveralthousandnucleosomesfromtheactualsiteoftheDSBandmaymarkthesurroundingchromatinforrecruitmentofproteinsrequiredforDNAdamagesignalingandrepair.Widespreadphosphorylationmayalsoservetoamplifythedamagesignaloraidrepairofpersistentlesions.PhosphorylationofSer-140inresponsetoionizingradiationismediatedbybothATMandPRKDCwhiledefectsinDNAreplicationinduceSer-140phosphorylationsubsequenttoactivationofATRandPRKDC.DephosphorylationofSer-140byPP2AisrequiredforDNADSBrepair.Inmeiosis,Ser-140phosphorylationmayoccuratsynaptonemalcomplexesduringleptoteneasanATM-dependentresponsetotheformationofprogrammedDSBsbySPO11.Ser-140phosphorylationmaysubsequentlyoccursatunsynapsedregionsofbothautosomesandtheXYbivalentduringzygotene,downstreamofATRandBRCA1activation.Ser-140phosphorylationmayalsoberequiredfortranscriptionalrepressionofunsynapsedchromatinandmeioticsexchromosomeinactivation(MSCI),wherebytheXandYchromosomescondenseinpachytenetoformtheheterochromaticXY-body.Duringimmunoglobulinclassswitchrecombinationinlymphocytes,Ser-140phosphorylationmayoccuratsitesofDNA-recombinationsubsequenttoactivationoftheactivation-inducedcytidinedeaminaseAICDA.&MonoubiquitinationofLys-120byRING1andRNF2/RING2complexgivesaspecifictagforepigenetictranscriptionalrepression(Bysimilarity). SIMILARITY:BelongstothehistoneH2Afamily.
MolecularWeight	~15kDa

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Millipore/AB10020 | Anti-acetyl-Histone H2A.X (Lys5) Antibody/AB10020/100 µg

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