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Millipore/AB1543 | Anti-Synapsin I Antibody/AB1543/50 µL

價格: ￥4188.00 市場價: 6980.00

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貨號: AB1543

品牌: Millipore

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Description
CatalogueNumber	AB1543
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-SynapsinIAntibody
AlternateNames	Synapsin-1
BackgroundInformation	SynapsinIisamemberofthesynapsinfamily.Synapsinsareneuronalphosphoproteinswhichassociatewiththecytoplasmicsurfaceofsynapticvesicles.Familymembersarecharacterizedbycommonproteindomains,andtheyareimplicatedinsynaptogenesisandthemodulationofneurotransmitterrelease,suggestingapotentialroleinseveralneuropsychiatricdiseases.Thismemberofthesynapsinfamilyplaysaroleinregulationofaxonogenesisandsynaptogenesis.Theproteinservesasasubstrateforseveraldifferentproteinkinasesandphosphorylationmayfunctionintheregulationofthisproteininthenerveterminal.MutationsoftheSynapsinIgenemaybeassociatedwithXlinkeddisorderswithprimaryneuronaldegenerationsuchasRettsyndrome.

ProductInformation
Format	Serum
Control	Mousehippocampalprimaryneurons,Mousebrainlysates,PC-12cells.
Presentation	Rabbitpolyclonalantiseruminbuffercontainingnopreservatives.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	DetectSynapsinIusingthisAnti-SynapsinIAntibodyvalidatedforuseinIC,IH(P),IP&WB.
KeyApplications	Immunocytochemistry Immunohistochemistry(Paraffin) Immunoprecipitation WesternBlotting
ApplicationNotes	Westernblotting: 1:200ofapreviouslotwasusedforlabeledProteinA,1:1,000dilutionforECL. Immunocytochemistry: 1:500-1:2,000dilutionofapreviouslotwasused. Immunoprecipitation: 5μLofapreviouslotquantitativelyimmunoprecipitatedallsynapsinin200μgofratbrain. Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	SynapsinI(mixtureofIa&Ib)purifiedfrombovinebrain.
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	SynapsinI(Mrof80,000and77,000).ImmunolabelingisblockedbypreadsorptionofantibodywithSynapsinI.SynapsinislocatedonlyinbrainnerveterminalandisanexcellentMarkerforsynapses.
SpeciesReactivity	Bovine Human Mouse Rat
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_006950.3
EntrezGeneSummary	Thisgeneisamemberofthesynapsingenefamily.Synapsinsencodeneuronalphosphoproteinswhichassociatewiththecytoplasmicsurfaceofsynapticvesicles.Familymembersarecharacterizedbycommonproteindomains,andtheyareimplicatedinsynaptogenesisandthemodulationofneurotransmitterrelease,suggestingapotentialroleinseveralneuropsychiatricdiseases.Thismemberofthesynapsinfamilyplaysaroleinregulationofaxonogenesisandsynaptogenesis.Theproteinencodedservesasasubstrateforseveraldifferentproteinkinasesandphosphorylationmayfunctionintheregulationofthisproteininthenerveterminal.MutationsinthisgenemaybeassociatedwithX-linkeddisorderswithprimaryneuronaldegenerationsuchasRettsyndrome.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified.
GeneSymbol	SYN1 SYN1a SYNI SYN1b
PurificationMethod	Unpurified
UniProtNumber	P17600
UniProtSummary	FUNCTION:SwissProt:P17600#Neuronalphosphoproteinthatcoatssynapticvesicles,bindstotheCytoskeleton,andisbelievedtofunctionintheregulationofneurotransmitterrelease.ThecomplexformedwithNOS1andCAPONproteinsisnecessaryforspecificnitric-oxidfunctionsatapresynapticlevel. SIZE:705aminoacids;74111Da SUBUNIT:Homodimer.InteractswithCAPON.FormsaternarycomplexwithNOS1(Bysimilarity). SUBCELLULARLOCATION:Celljunction,synapse. PTM:Substrateofatleastfourdifferentproteinkinases.Itisprobablethatphosphorylationplaysaroleintheregulationofsynapsin-1inthenerveterminal.PhosphorylateduponDNAdamage,probablybyATMorATR. DISEASE:SwissProt:P17600#DefectsinSYN1areacauseofX-linkedrecessiveepilepsyassociatedwithvariablelearningdisABIlitiesandbehaviordisorders[MIM:300491]. SIMILARITY:SwissProt:P17600##Belongstothesynapsinfamily.
MolecularWeight	77&80kDa

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Millipore/AB1543 | Anti-Synapsin I Antibody/AB1543/50 µL

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