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Millipore/AB1783 | Anti-Glutamate Transporter Antibody, Glial/AB1783/50 µL

價格: ￥4440.00 市場價: 7400.00

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貨號: AB1783

品牌: Millipore

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Description
CatalogueNumber	AB1783
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-GlutamateTransporterAntibody,Glial
AlternateNames	GLT-1 EAAT2
BackgroundInformation	Glutamatetransporters(GluT)functiontoremoveL-glutamate(Glu),theprimaryexcitatoryneurotransmitterinthemammaliancentralnervoussystem(CNS),fromthesynapticcleft.ByclearingthesynapseinthismannerGlucanberecycledforlateruse,theproperdiffusiongrADIentcanbemaintainedandexcitotoxicitycanbeprevented.TherehavebeenreportsofmanydifferentmembersofaGluTmultigenefamily;GLT1,GLAST,EAAC1andEAAT2.mRNAhasbeenidentifiedinbrainforeachoftheseproteins. EAAT2transportsL-glutamateandalsoL-andD-aspartate.Itisessentialforterminatingthepostsynapticactionofglutamatebyrapidlyremovingreleasedglutamatefromthesynapticcleft.Actsasasymportbycotransportingsodium.

ProductInformation
Format	Serum
Control	Ratbraintissue
Presentation	Guineapigantiserumcontainingnopreservatives.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt.

Applications
Application	DetectGlutamateTransporterusingthisAnti-GlutamateTransporterAntibody,GlialvalidatedforuseinIH(P),IF&WB.
KeyApplications	Immunohistochemistry(Paraffin) Immunofluorescence WesternBlotting
ApplicationNotes	EvaluatedbyWesternBlotonmousebrainmembranelysates. WesternBlot:1:500dilutionofthisantibodydetectedGLT-1on10ugofmousebrainmembranelysates. Immunohistochemistry: 1:1,000-1:4,000dilutionfromapreviuoslotusedaDABdetectionsystemonadultratforebrainfixedwith4%paraformaldehyde. Immunohistochemistry: 1:5,000-10,000dilutionfromapreviuoslotusedacyanineconjugatedsecondaryantibody. Enzymaticdetectionrequiressubstantiallyhigherprimaryantibodydilutions.Lightlyfixed4%PFAmaterialisrecommended. Notes: MaleSprague-Dawleyrats(b.wt.100-150g)wereanesthetizedwithsodiumpentobarbitalandperfusedviatheascendingaortawith50mLofCa2+-freeTyrode+ssolutionfollowedbyaformalin-picricacidfixative(4%paraformaldehydewith0.4%picricacidin0.16Mphosphatebuffer,pH6.9)for6minutes.Tissueswererapidlydissectedout,postfixedinthesamefixativefor90minutesandrinsedforatleast24hoursin0.1Mphosphatebuffer(pH7.4)containing10%sucrose.Sectionswerecut(14um)inacryostatandincubatedat4°CovernightwithAB1783(1:5,000-1:10,000).AfterrinsinginPBSsectionswereincubatedfor60minutesatroomtemperaturewithCy3-conjugatedsecondaryantibodies.AftermountinginamixtureofPBSandglycerol(1:3)containing0.1%p-phenylenediamine,sectionswereexaminedwithaNikonMicrophot-SAepifluorescencemicroscope. Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	Syntheticpeptidefromthecarboxy-terminusofratGLT-1.
Epitope	C-terminus
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	GuineaPig
Specificity	GlialGlutamateTransporterGLT-1(EAAT2).Theantibodyhasbeentestedoncentralnervoussystemtissue.Preabsorptionoftheantiserumwiththeimmunogenpeptide(CatalognumberAG391)completelyabolishestheimmunostaining.
SpeciesReactivity	Human Mouse Rat
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_004171.3
EntrezGeneSummary	Thisgeneencodesamemberofafamilyofsolutetransporterproteins.Themembrane-boundproteinistheprincipaltransporterthatclearstheexcitatoryneurotransmitterglutamatefromtheextracellularspaceatsynapsesinthecentralnervoussystem.Glutamateclearanceisnecessaryforpropersynapticactivationandtopreventneuronaldamagefromexcessiveactivationofglutamatereceptors.Mutationsinanddecreasedexpressionofthisproteinareassociatedwithamyotrophiclateralsclerosis.Alternativelysplicedtranscriptvariantsofthisgenehavebeendescribed,buttheirfull-lengthnatureisnotknown.
GeneSymbol	SLC1A2 GLT-1 EAAT2 GLT1
PurificationMethod	Unpurified
UniProtNumber	P43004
UniProtSummary	FUNCTION:SwissProt:P43004#TransportsL-glutamateandalsoL-andD-aspartate.Essentialforterminatingthepostsynapticactionofglutamatebyrapidlyremovingreleasedglutamatefromthesynapticcleft.Actsasasymportbycotransportingsodium. SIZE:574aminoacids;62104Da SUBUNIT:Homotrimer. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. PTM:Glycosylated. SIMILARITY:SwissProt:P43004##Belongstothesodium:dicarboxylate(SDF)symporter(TC2.A.23)family.
MolecularWeight	~62kDa

PhysicochemicalInformation

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Millipore/AB1783 | Anti-Glutamate Transporter Antibody, Glial/AB1783/50 µL

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