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Millipore/AB1899 | Anti-Caspase 3 Antibody, large subunit & proform/AB1899/50 µg

價格: ￥4068.00 市場價: 6780.00

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貨號: AB1899

品牌: Millipore

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Description
CatalogueNumber	AB1899
Replaces	04-439
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-Caspase3Antibody,largesubunit&proform
AlternateNames	apopain procaspase3
BackgroundInformation	Caspase-3(CPP32,Apopain)isthemostextensivelystudiedapoptoticprotein.Caspase-3issynthesizedasaninactiveproenzyme(32kDa)thatisprocessedincellsundergoingapoptosisbyself-proteolysisand/orcleavagebyanotherupstreamprotease.Theprocessedformofcaspase-3consistsoflarge(17kDa)andsmall(12kDa)subunitswhichassociatetoformanactiveenzyme.Theactivecaspase-3proteolyticallycleavesandactivatesothercaspases,aswellasrelevanttargetsinthecellssuchasPARPandDFF.

ProductInformation
Format	AffinityPurified
Control	Skin/Tumor,Embryo
Presentation	PurifiedrabbitpolyclonalliquidinPBS,pH7.2,containing50%glycerol,1%BSAand0.02%thimerosal.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	ThisAnti-Caspase3Antibody,largesubunit&proformisvalidatedforuseinWBforthedetectionofCaspase3.
KeyApplications	WesternBlotting
ApplicationNotes	Westernblot: A1:100-1:200dilutionofapreviouslotwasusedinWB. Optimalworkingdilutionsmustbedeterminedbyenduser.

BIOLOGicalInformation
Immunogen	Syntheticpeptide
Epitope	Largesubunit&proform
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	AB1899detectsprocaspase-3(32kDa)andthecleavedp20fragmentincellsundergoingapoptosis.
SpeciesReactivity	Human Mouse Rat
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_004346.3
EntrezGeneSummary	Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Thisproteincleavesandactivatescaspases6,7and9,andtheproteinitselfisprocessedbycaspases8,9and10.Itisthepredominantcaspaseinvolvedinthecleavageofamyloid-beta4Aprecursorprotein,whichisassociatedwithneuronaldeathinAlzheimer"sdisease.Alternativesplicingofthisgeneresultsintwotranscriptvariantsthatencodethesameprotein.
GeneSymbol	CASP3 CPP-32 Yama CASP-3 CPP32B SCA-1 CPP32 EC3.4.22.56[Contains:Caspase-3subunitp17Caspase-3subunitp12].
PurificationMethod	Affinitypurifiedimmunoglobulin
UniProtNumber	P42574
UniProtSummary	FUNCTION:SwissProt:P42574#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Attheonsetofapoptosisitproteolyticallycleavespoly(ADP-ribose)polymerase(PARP)ata"216-Asp--Gly-217"bond.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs)betweenthebasichelix-loop-helixleucinezipperdomainandthemembraneattachmentdomain.Cleavesandactivatescaspase-6,-7and-9.Involvedinthecleavageofhuntingtin. SIZE:277aminoacids;31608Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya17kDa(p17)anda12kDa(p12)subunit. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyexpressedinlung,spleen,heart,liverandkidney.Moderatelevelsinbrainandskeletalmuscle,andlowintestis.Alsofoundinmanycelllines,highestexpressionincellsoftheimmunesystem. PTM:CleavagebygranzymeB,caspase-6,caspase-8andcaspase-10generatesthetwoactivesubunits.Additionalprocessingofthepropeptidesislikelyduetotheautocatalyticactivityoftheactivatedprotease.Activeheterodimersbetweenthesmallsubunitofcaspase-7proteaseandthelargesubunitofcaspase-3alsooccurandviceversa. SIMILARITY:SwissProt:P42574##BelongstothepeptidaseC14family.
MolecularWeight	45kDafulllength,32-35kDapartialintermediateandthecleavedp17/20kDafragmentincellsundergoingapoptosis

PhysicochemicalInformation

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Millipore/AB1899 | Anti-Caspase 3 Antibody, large subunit & proform/AB1899/50 µg

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