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Millipore/AB1956 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr731]/AB1956/100 µL

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貨號: AB1956

品牌: Millipore

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Description
CatalogueNumber	AB1956
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-VE-CadherinAntibody,phospho-specific[Tyr731]
AlternateNames	Cadherin-5 Vascularendothelial-cadherin CD144
BackgroundInformation	VE-cadherinisanendothelialspecificadhesionmoleculethatisessentialforthemaintenanceofendothelialbarrierfunctionandangiogenesis.ItislinkedtotheactinCytoskeletonthroughanumberofadaptorproteinsincludingalpha,beta,andgammacatenin.CytoskeletaldynamicsandphosphorylationregulateVE-cadherinmediatedcell-celladhesion.Phosphorylationoftyrosine731leadstotheseparationofbeta-cateninfromthecytoplasmictailofVE-cadherin.Thisphosphorylationeventissufficienttomaintaincellsinamesenchymalstateduringthecellinvasionphaseofangiogenesis.

ProductInformation
Format	AffinityPurified
Presentation	Antibodyiscross-adsorbedtononphospho-peptidecorrespondingtothesiteofphosphorylationthenaffinitypurifiedusingphosphorylatedVE-cadherin(Tyr731)peptide.Antibodyissuppliedin100μLphosphate-bufferedsaline(noCa²⁺,noMg²⁺),pH7.3,50%glycerol,1mg/mLBSA,and0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Maintainat-20°Cforuptooneyearfromdateofreceipt.Avoidrepeatedfreeze/thawcycles.Maybestoredforshortperiodsat2-8°C.

Applications
Application	Anti-VE-CadherinAntibody,phospho-specific[Tyr731]isanantibodyagainstVE-CadherinforuseinWB.
KeyApplications	WesternBlotting
ApplicationNotes	WesternBlot:1:1000. Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	Syntheticpeptidecorrespondingtoaminoacidresiduessurroundingandincludingtyrosine731(phosphorylated)ofhumanVE-Cadherin.Theimmunogensequenceis100%identicalinchimpanzee,mouse,rat,chicken,zebrafish,cow,dogand91%identicalinpigVE-cadherin.
Epitope	Tyr731
Host	Rabbit
Specificity	Theantibodydetectsa120kDaproteincorrespondingtoVE-cadherin.
SpeciesReactivity	Human
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_001795.2
EntrezGeneSummary	Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined.
GeneSymbol	CDH5 VE-cadherin CD144 7B4
Modifications	Phosphorylation
PurificationMethod	ImmunoAffinityPurified
UniProtNumber	P33151
UniProtSummary	FUNCTION:SwissProt:P33151#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton. SIZE:784aminoacids;87516Da SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein(Probable).Note=Foundatcell-cellboundariesandprobablyatcell-matrixboundaries. TISSUESPECIFICITY:Endothelialtissuesandbrain. SIMILARITY:SwissProt:P33151##Contains5cadherindomains.
MolecularWeight	120kDa

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Millipore/AB1956 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr731]/AB1956/100 µL

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