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Millipore/AB2253 | Anti-Doublecortin Antibody/AB2253/50 µL

價格: ￥4932.00 市場價: 8220.00

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貨號: AB2253

品牌: Millipore

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Description
CatalogueNumber	AB2253
Replaces	AB5910
Description	Anti-DoublecortinAntibody
AlternateNames	doublecortex lissencephaly,X-linked(doublecortin)
BackgroundInformation	Doublecortin(DCX)isamicrotubule-associatedproteinexpressedalmostexclusivelyinimmatureneurons.NeuronalprecursorsbegintoexpressDCXshortlyafterexitingthecellcycle,andcontinuetoexpressDCXfor2-3weeksasthecellsmatureintoneurons.DownregulationofDCXbeginsafter2weeks,andoccursatthesametimethatthesecellsbegintoexpress,aMarkerformatureneurons.DuetothenearlyexclusiveexpressionofDCXindevelopingneurons,thisproteinhasbeenusedincreasinglyasamarkerforneurogenesis.Indeed,thelevelsofDCXexpressionincreaseinresponsetoexercise,whichoccursinparallelwithincreasedBrdUlabelling,currentlya"goldstandard"inmeasuringneurogenesis.

ProductInformation
Format	Serum
Control	RatBrainlysate.
Presentation	GST-DepletedSerawith0.05%NaN3.

StorageandShippingInformation
StorageConditions	Maintainat-20°Cinundilutedaliquotsforupto1yearafterdateofreceipt.

Applications
Application	ThisAnti-DoublecortinAntibodyisvalidatedforuseinWB,IH,ICforthedetectionofDoublecortin.
KeyApplications	WesternBlotting Immunohistochemistry Immunocytochemistry
ApplicationNotes	Immunohistochemistry: 1:1,000–1:15,000onfreefloatingbrainsections.Optimaldilutionsneedtobedeterminedbytheenduser. Immunocytochemistry: Testedonmouseprimaryneurons.Optimaldilutionsmustbedeterminedbyenduser.

BIOLOGicalInformation
Immunogen	RecombinantPeptide.
Epitope	C-Terminus
Host	GuineaPig
Specificity	Cat.#AB2253recognizestheC-TerminusofDoublecortin.
SpeciesReactivity	Rat Mouse
SpeciesReactivityNote	MouseandRat.Expectedtoreactwithhumanbasedonsequencehomology.Reactivitywithotherspecieshasnotbeendetermined.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NC_000086.7
EntrezGeneSummary	Inthedevelopingcortex,corticalneuronsmustmigrateoverlongdistancestoreachthesiteoftheirfinaldifferentiation.TheproteinencodedbythisgeneisacytoplasmicproteinwhichappearstodirectneuronalmigrationbyregulatingtheorganizationandstABIlityofmicrotubules.Theencodedproteincontainstwodoublecortindomains,whichbindmicrotubules.Inaddition,theencodedproteininteractswithLIS1,theregulatorygammasubunitofplateletactivatingfactoracetylhydrolase,andthisinteractionisimportanttopropermicrotubulefunctioninthedevelopingcortex.MutationsinthisgeneareacauseofX-linkedlissencephaly.Multipletranscriptvariantsencodingatleastthreedifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq]
GeneSymbol	DBCN DC Doublin LISX Lis-X Lissencephalin-X OTTHUMP00000062892 SCLH XLIS doublecortex doublecortin doublin lissencephalin-X
PurificationMethod	GSTDepletion
UniProtNumber	088809
UniProtSummary	FUNCTION:Seemstoberequiredforinitialstepsofneuronaldispersionandcortexlaminationduringcerebralcortexdevelopment.MayactbycompetingwiththeputativeneuronalproteinkinaseDCAMKL1inbindingtoatargetprotein.Mayinthatwayparticipateinasignalingpathwaythatiscrucialforneuronalinteractionbeforeandduringmigration,possIBLyaspartofacalciumion-dependentsignaltransductionpathway.MaybepartwithLIS-1ofanoverlapping,butdistinct,signalingpathwaysthatpromoteneuronalmigration. SUBUNITSTRUCTURE:Interactswithtubulin. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyexpressedinneuronalcellsoffetalbrain(inthemajorityofcellsofthecorticalplate,intermediatezoneandventricularzone),butnotexpressedinotherfetaltissues.Intheadult,highlyexpressedinthebrainfrontallobe,butverylowexpressioninotherregionsofbrain,andnotdetectedinheart,placenta,lung,liver,skeletalmuscles,kidneyandpancreas. DISEASE:DefectsinDCXarethecauseoflissencephalyX-linkedtype1(LISX1)[MIM:300067];alsocalledX-LISorLIS.LISX1isaclassiclissencephalycharacterizedbymentalretardationandseizuresthataremoresevereinmalepatients.Affectedboysshowanabnormallythickcortexwithabsentorseverelyreducedgyri.Clinicalmanifestationsincludefeedingproblems,abnormalmusculartone,seizuresandseveretoprofoundpsychomotorretardation.Femalepatientsdisplayalessseverephenotypereferredtoas"doublecortex".Ref.1Ref.2Ref.9Ref.10Ref.18Ref.21 DefectsinDCXarethecauseofsubcorticalbandheterotopiaX-linked(SBHX)[MIM:300067];alsoknownasdoublecortexorsubcorticallaminarheterotopia(SCLH).SBHXisamildbrainmalformationofthelissencephalyspectrum.Itischaracterizedbybilateralandsymmetricplatesorbandsofgraymatterfoundinthecentralwhitematterbetweenthecortexandcerebralventricles,cerebralconvolutionsusuallyappearingnormal.Ref.11Ref.12Ref.13Ref.14Ref.15Ref.16Ref.17Ref.19 AchromosomalaberrationinvolvingDCXisfoundinlissencephaly.Translocationt(X;2)(q22.3;p25.1). SEQUENCESIMILARITY:Contains2doublecortindomains.
MolecularWeight	Approx.45kDa.

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Millipore/AB2253 | Anti-Doublecortin Antibody/AB2253/50 µL

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