| Immunogen | Syntheticpeptidecorrespondingtoaminoacids100-116ofmurinecaspase-12. | 
| Epitope | prodomain,aa100-116 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | Antibodyrecognizescaspase-12pro-proteininmouseextractsofnormalandapoptoticcells.Caspase-12ispredictedtohavealarge,>120aa,longprodomainregion.Thusthisantibodyrecognizesonlytheproformsoftheenzymeandnottheactivesubunits.Uncleaved(proform)caspase-12isprominentlydetectedinmanytissues.Activeformsaredifficulttodetectexpectintransfectcellsystems.{Kalai,Metal(2003)162:457-467}. | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneSummary | CaspasesarecysteineproteasesthatcleaveC-terminalasparticacidresiduesontheirsubstratemolecules.Thisgene,CASP12,ismosthighlyrelatedtomembersoftheICEsubfamilyofcaspasesthatprocessinflammatorycytokines.Inrodents,thehomologofthisgenemediatesapoptosisinresponsetoendoplasmicreticulumstress.However,inhumansthisgenecontainsapolymorphismforthepresenceorabsenceofaprematurestopcodon.Themajorityofhumanindividualshavetheprematurestopcodonandproduceatruncatednon-functionalprotein.Theread-throughcodonoccursprimarilyinindividualsofAfricandescentandcarriershaveendotoxinhypo-responsivenessandanincreasedsusceptibilitytoseveresepsis. | 
| GeneSymbol | - CASP12
 - Caspase-12.
 - CASP12P1
 
  | 
| PurificationMethod | ImmunoAffinityPurified | 
| UniProtNumber |  | 
| UniProtSummary | SIZE:341aminoacids;38907Da |