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Millipore/AB4250 | Anti-CXC Chemokine Receptor 3 Antibody, CT domain/AB4250/50 µg

價格: ￥4308.00 市場價: 7180.00

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貨號: AB4250

品牌: Millipore

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Description
CatalogueNumber	AB4250
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-CXCChemokineReceptor3Antibody,CTdomain
AlternateNames	CXCR3
BackgroundInformation	CXCR3,achemokinereceptor,ishighlysimilartotheinterleukin8BreceptorandhasbeenshowntomediaterecruitmentofTcellstositesofinflammationandretentionofT-cellsintheinflamedCNS.CXCR3hasbeensuggestedtobetheprincipalinflammatorychemokinereceptorinvolvedinintrathecalaccumulationofT-cellsinmultiplesclerosisanddiabetes.ItisexpressedonmalignantBcellsinchroniclymphoproliferativedisorders(Jonesetal.,2000).Analternativelysplicedisoform,CXCR3B,hasrecentlybeenidentified(Lasagnietal.,2003).CXCR3expressionhasbeendocumentedinthebrain,lymphoidandotherperipheraltissues,andindiseasesincludingatherosclerosis,Alzheimer"s,multiplesclerosis,rheumatoidarthritis,lymphomas,asthma,neoplasms,leukemia,andinflammatoryconditionsofvariousorgans.

ProductInformation
Format	AffinityPurified
Presentation	Peptide-affinitypurifiedimmunoglobulin.Liquidinphosphatebufferedsaline,pH7.7,containing0.01%sodiumazide

StorageandShippingInformation
StorageConditions	Maintainat-70°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.Maybestoredat2-8°Cforshorttermuse.Avoidrepeatedfreeze/thawcycles.

Applications
Application	Anti-CXCChemokineReceptor3Antibody,C-terminaldomaindetectslevelofCXCChemokineReceptor3&hasbeenpublished&validatedforuseinIH(P).
KeyApplications	Immunohistochemistry(Paraffin)
ApplicationNotes	Immunohistochemistry(formalin-fixedparaffin-embeddedtissues) Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	SyntheticpeptidecorrespondingtoasequencewithintheC-terminaldomainofhumanCXCR3.Theimmunogenhas82%homologywithratandmouse.
Epitope	C-terminaldomain
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	RecognizeshumanCXCR3.ThespecificityofthisantibodyhasbeenevaluatedbyIHCstainingofhumantonsil.
SpeciesReactivity	Human
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_001504.1
EntrezGeneSummary	CD183isaGprotein-coupledreceptorwithselectivityforthreechemokines,termedIP10(interferon-g-inducIBLe10kDaprotein),Mig(monokineinducedbyinterferon-g)andI-TAC(interferon-inducibleTcella-chemoattractant).IP10,MigandI-TACbelongtothestructuralsubfamilyofCXCchemokines,inwhichasingleaminoacidresidueseparatesthefirsttwooffourhighlyconservedCysresidues.Historically,CD183isthethirdCXCchemokinereceptordiscoveredand,therefore,commonlydesignatedasCXCR3.BindingofchemokinestoCD183inducescellularresponsesthatareinvolvedinleukocytetraffic,mostnotablyintegrinactivation,cytoskeletalchangesandchemotacticmigration.InhibitionbyBordetellapertussistoxinsuggeststhatheterotrimericGproteinoftheGi-subclasscoupletoCD183.Signaltransductionhasnotbeenfurtheranalyzedbutmayincludethesameenzymesthatwereidentifiedinthesignalingcascadeinducedbyotherchemokinereceptors.Asaconsequenceofchemokine-inducedcellulardesensitization(phosphorylation-dependentreceptorinternalization),cellularresponsesaretypicallyrapidandshortinduration.Cellularresponsivenessisrestoredafterdephosphorylationofintracellularreceptorsandsubsequentrecyclingtothecellsurface.AhallmarkofCD183isitsprominentexpressionininvitroculturedeffector/memoryTcells,andinTcellspresentinmanytypesofinflamedtissues.Inaddition,IP10,MigandI-TACarecommonlyproducedbylocalcellsininflammatorylesion,suggestingthatCD183anditschemokinesparticipateintherecruitmentofinflammatorycells.Therefore,CD183isatargetforthedevelopmentofsmallmolecularweightantagoNISTs,whichmaybeusedinthetreatmentofdiverseinflammatorydiseases.
GeneSymbol	CXCR3 CD182 CXC-R3 IP10-R IP10 Mig-R CD183 CKR-L2 CMKAR3 GPR9 CXCR-3 MigR
UniProtNumber	P49682
UniProtSummary	FUNCTION:SwissProt:P49682#ReceptorforCXCL9,CXCL10andCXCL11andmediatestheproliferationofhumanmesangialcells(HMC).Isoform2isareceptorforCXCL4andalsomediatestheinhibitoryactivitiesofCXCL9,CXCL10andCXCL11onthegrowthofhumanmicrovascularendothelialcells(HMVEC).Isoform2mayplayaroleinangiogenesis.Isoform3mediatesactivityofCXCL11. SIZE:368aminoacids;40660Da SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Isoform1andisoform2aremainlyexpressedinheart,kidney,liverandskeletalmuscle.Isoform1isalsoexpressedinplacenta. SIMILARITY:SwissProt:P49682##BelongstotheG-proteincoupledreceptor1family.

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Millipore/AB4250 | Anti-CXC Chemokine Receptor 3 Antibody, CT domain/AB4250/50 µg

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