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Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg

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貨號: AB4251

品牌: Millipore

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Description
CatalogueNumber	AB4251
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-CXCChemokineReceptor4Antibody,NT,extracellular
AlternateNames	CXCR4
BackgroundInformation	CXCR4isachemokinereceptorinvolvedinorganvascularization,neuronalcellmigration,andpatterningofthecentralnervoussystemduringdevelopment.Itbindsstromalcell-derivedfactor1(SDF1)andmediatesmigrationofrestingleukocytesandisuniqueinhominghematopoieticProgenitorstobonemarrow.ThesepropertiessuggestthatCXCR4isinvolvedintumorcellmigrationandlocaltumorinvasion.ItisalsoanHIV-1fusionco-factorthatallowsHIV-1invasionindiversehumancelltypes.CXCR4hastwoisoformsthatareproducedbyalternativesplicingandhasbeenreportedtobeexpressedincellsoftheimmuneandcentralnervoussystems.Itishighlyexpressedinbrainandheart,andinwhitebloodcells,vascularendothelialcells,andumbilicalcordendothelialcells.Inbraintumors,CXCR4isexpressedinregionsofangiogenesisanddegenerative,necrotic,andmicrocysticchanges(Rempeletal.,2000).ESTshavebeenisolatedfromawidevarietyoftissuelibraries,particularlyuterus,kidney,lung,tonsil,andbrain.

ProductInformation
Format	AffinityPurified
Presentation	Peptide-affinitypurifiedimmunoglobulin.Liquidinphosphatebufferedsaline,pH7.7,containing0.01%sodiumazide

StorageandShippingInformation
StorageConditions	Maintainat-70°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.Maybestoredat2-8°Cforshorttermuse.Avoidrepeatedfreeze/thawcycles.

Applications
Application	ThisAnti-CXCChemokineReceptor4Antibody,N-terminal,extracellularisvalidatedforuseinIH(P)forthedetectionofCXCChemokineReceptor4.
KeyApplications	Immunohistochemistry(Paraffin)
ApplicationNotes	Immunohistochemistry(formalin-fixedparaffin-embeddedtissues) Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	SyntheticpeptidecorrespondingtoasequencewithintheN-terminalextracellulardomainofhumanCXCR4.Theimmunogenhas93%homologywithmouseandrat.
Epitope	N-terminal,extracellular
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	RecognizeshumanCXCR4.ThespecificityofthisantibodyhasbeenconfirmedbyIHCstainingofcardiacmyocytesinhumanheart.
SpeciesReactivity	Human
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_001008540.1 NM_003467.2
EntrezGeneSummary	ThisgeneencodesaCXCchemokinereceptorspecificforstromalcell-derivedfactor-1.Theproteinhas7transmembraneregionsandislocatedonthecellsurface.ItactswiththeCD4proteintosupportHIVentryintocellsandisalsohighlyexpressedinbreastcancercells.MutationsinthisgenehavebeenassociatedwithWHIM(warts,hypogammaglobulinemia,infections,andmyelokathexis)syndrome.Alternatetranscriptionalsplicevariants,encodingdifferentisoforms,havebeencharacterized.
GeneSymbol	CXCR4 WHIM NPY3R NPYY3R FB22 LAP3 Fusin CXCR-4 LCR1 NPYR HM89 fusin HSY3RR CXC-R4 NPYY3 NPYRL CD184 D2S201E LESTR
UniProtNumber	P61073
UniProtSummary	FUNCTION:SwissProt:P61073#ReceptorfortheC-X-CchemokineCXCL12/SDF-1.Transducesasignalbyincreasingtheintracellularcalciumionslevel.Involvedinhaematopoiesisandincardiacventricularseptumformation.Playsalsoanessentialroleinvascularizationofthegastrointestinaltract,probablybyregulatingvascularbranchingand/orremodelingprocessesinendothelialcells.Couldbeinvolvedincerebellardevelopment.IntheCNS,couldmediatehippocampal-neuronsurvival.Actsasacoreceptor(CD4beingtheprimaryreceptor)forHIV-1X4isolatesandasaprimaryreceptorforsomeHIV-2isolates.PromotesEnv-mediatedfusionofthevirus. SIZE:352aminoacids;39746Da SUBUNIT:InteractswithHIV-1surfaceproteingp120andTat. SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Expressedinnumeroustissues,suchasperipheralbloodleukocytes,spleen,thymus,spinalcord,heart,placenta,lung,liver,skeletalmuscle,kidney,pancreas,cerebellum,cerebralcortexandmedulla(inmicrogliaaswellasinastrocytes),brainmicrovascular,coronaryarteryandumbilicalcordendothelialcells.Isoform1ispredominantinalltissuestested. DOMAIN:SwissProt:P61073Theamino-terminusiscriticalforligandbinding.ResiduesinallfourextracellularregionscontributetoHIV-1coreceptoractivity. PTM:Sulfated. DISEASE:SwissProt:P61073#DefectsinCXCR4areacauseofWHIMsyndrome[MIM:193670];alsocalledwarts,hypogammaglobulinemia,infections,andmyelokathexis.WHIMsyndromeisanimmunodeficiencydiseasecharacterizedbyneutropenia,hypogammaglobulinemiaandextensivehumanpapillomavirus(HPV)infection.Despitetheperipheralneutropenia,bonemarrowaspiratesfromaffectedindividualscontainabundantmaturemyeloidcells,aconditiontermedmyelokathexis. SIMILARITY:BelongstotheG-proteincoupledreceptor1family.

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Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg

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