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Millipore/AB5320B | Anti-NG2 Chondroitin Sulfate Proteoglycan, Biotin Conjugate Antibody/AB5320B/100 µL

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貨號: AB5320B

品牌: Millipore

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Description
CatalogueNumber	AB5320B
Description	Anti-NG2ChondroitinSulfateProteoglycan,BiotinConjugateAntibody
AlternateNames	Chondroitinsulfateproteoglycan4 ChondroitinsulfateproteoglycanNG2 Melanomachondroitinsulfateproteoglycan Melanoma-associatedchondroitinsulfateproteoglycan
BackgroundInformation	NG2isahighmolecularweight,integralmembranechondroitinsulfateproteoglycan.Itisfoundonthesurfacesofanunusualclassofglialcellswithinthedevelopingandmaturecentralnervoussystemthathavethepropertiesofoligodendrocyteprecursorcells(i.e.,O-2AProgenitorcells).NG2isalsofoundonthesurfacesofchondroblasts,proliferatingcapillaryendothelialcells,somehumanmelanomacelllines,andonleukemicblastsinchildhoodacutelymphoblasticleukemia.TheNG2proteoglycanislikelytoplayaroleinregulationofcellmotility,axonoutgrowthandthecellularresponsestoplatelet-derivedgrowthfactor.

ProductInformation
Format	Biotin
Control	Cryosectionsofratcortextissue
Presentation	PurifiedrabbitpolyclonalconjugatedtoBiotininPBSwith0.1%sodiumazideand15mg/mLBSA.

StorageandShippingInformation
StorageConditions	Maintainrefrigeratedat2-8°Cinundilutedaliquotsforupto6monthsfromdateofreceipt.

Applications
Application	Anti-NG2ChondroitinSulfateProteoglycan,BiotinConjugateAntibodyisanantibodyagainstNG2ChondroitinSulfateProteoglycanforuseinIHC,ICC.
KeyApplications	Immunohistochemistry Immunocytochemistry
ApplicationNotes	ImmunohistochemistryAnalysis:A1:100dilutionfromarepresentativelotdetectedNG2inparaffinembeddedratcortextissue. ImmunocytochemistryAnalysis:A1:100dilutionfromarepresentativelotdetectedNG2inratoligodendrocyteprecursorcells.PerformedwithoutTriton.

BIOLOGicalInformation
Immunogen	ImmunoaffinitypurifiedNG2ChondroitinSulfateProteoglycanfromrat
Host	Rabbit
Specificity	ThisantibodyidentifiestheintactproteoglycanandcoreproteinbyWBandELISA.Whenoligodendrocyteprecursorcells(i.e.O-2Aprogenitorcells)arestainedalive,thestainappearsasclustersonthecellsurface.Thisantibodydoesnotstaindifferentiatedoligodendrocyteswell.
SpeciesReactivity	Rat Mouse Human Monkey
SpeciesReactivityNote	DemonstratedtoreactwithRat.PredictedtoreactwithMouse,Human,andMonkeybasedon100%sequencehomology.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_001888
EntrezGeneSummary	Ahumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreADIngonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
GeneSymbol	CSPG4 MCSP
PurificationMethod	ProteinAPurfied
UniProtNumber	Q6UVK1
UniProtSummary	FUNCTION:Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades. SIZE:2322aminoacids;250497Da SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16. SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity). TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells. PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity). SIMILARITY:Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains. MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells
MolecularWeight	Theunconjugatedparentantibody(Cat.No.AB5320)hasanobservedmolecularweightat~270-300kDa.

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Millipore/AB5320B | Anti-NG2 Chondroitin Sulfate Proteoglycan, Biotin Conjugate Antibody/AB5320B/100 µL

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