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Millipore/AB5388 | Anti-Synphilin-1 Antibody, a.a. 829-847/AB5388/50 µL

價格: ￥3948.00 市場價: 6580.00

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貨號: AB5388

品牌: Millipore

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Description
CatalogueNumber	AB5388
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-Synphilin-1Antibody,a.a.829-847
AlternateNames	Alpha-SynucleinInteractingProtein

ProductInformation
Format	Serum
Presentation	Rabbitserum.Lyophilized.Containsnopreservative.Reconstitutewith50μLofsteriledistilledwater.Centrifugeifnecessarytoremoveanyresidue.

StorageandShippingInformation
StorageConditions	Maintainlyophilizedmaterialat-20°Cto-70°Cforupto6months.Afterreconstitutionmaintainfrozenat-20°Cinundilutedaliquotsforupto6months.Avoidrepeatedfreeze/thawcycles.

Applications
Application	Anti-Synphilin-1Antibody,a.a.829-847detectslevelofSynphilin-1&hasbeenpublished&validatedforuseinIH.
KeyApplications	Immunohistochemistry
ApplicationNotes	Immunohistochemistry:1:1,000-1:2,000. Note:TheantibodyhasalsobeenusedsuccessfullyforWesternblotbutresultsmayvaryfromlabtolab.TheusefulnessoftheantibodyforWesternblotmustbedeterminedbyeachindividuallaboratory. Optimalworkingdilutionsmustbedeterminedbyenduser.

BIOLOGicalInformation
Immunogen	Asyntheticpeptidefromhumansynphilin-1(aminoacids829-847).
Epitope	a.a.829-847
Host	Rabbit
Specificity	Synphilin-1.Immunohistochemicalanalysisofhumanbrainindicatesahighlevelofspecificity.Peptidesequenceusedshows88%sequencehomologywithmousesynphilin-1butmousehasnotbeentestedforreactivity.
SpeciesReactivity	Human Rat
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_005460.2
EntrezGeneSummary	Thisgeneencodesaproteincontainingseveralprotein-proteininteractiondomains,includingankyrin-likerepeats,acoiled-coildomain,andanATP/GTP-bindingmotif.Theencodedproteininteractswithalpha-synucleininneuronaltissueandmayplayaroleintheformationofcytoplasmicinclusionsandneurodegeneration.AmutationinthisgenehasbeenassociatedwithParkinson"sdisease.Alternativelysplicedtranscriptvariantsencodingdifferentisoformsofthisgenehavebeendescribed,buttheirfull-lengthnaturehasyettobedetermined.
GeneSymbol	SNCAIP MGC39814 synphilin-1 SYPH1 Synphilin-1
UniProtNumber	Q9Y6H5
UniProtSummary	SIZE:919aminoacids;100381Da SUBUNIT:AssociateswithSNCA,RNF19AANDPARK2. TISSUESPECIFICITY:Widelyexpressed,withhighestlevelsinbrain,heartandplacenta. PTM:Ubiquitinated;mediatedbySIAH1orRNF19AandleADIngtoitssubsequentproteasomaldegradation. DISEASE:SwissProt:Q9Y6H5#DefectsinSNCAIPareacauseofParkinsondisease(PD)[MIM:168600].PDisacomplex,multifactorialdisorderthattypicallymanifestsaftertheageof50years,althoughearly-onsetcases(before50years)areknown.PDgenerallyarisesasasporadicconditionbutisoccasionallyinheritedasasimplemendeliantrait.AlthoughsporadicandfamilialPDareverysimilar,inheritedformsofthediseaseusuallybeginatearlieragesandareassociatedwithatypicalclinicalfeatures.PDischaracterizedbybradykinesia,restingtremor,muscularrigidityandposturalinstABIlity,aswellasbyaclinicallysignificantresponsetotreatmentwithlevodopa.ThepathologyinvolvesthelossofdopaminergicneuronsinthesubstantianigraandthepresenceofLewybodies(intraneuronalaccumulationsofaggregatedproteins),insurvivingneuronsinvariousareasofthebrain. SIMILARITY:SwissProt:Q9Y6H5##Contains6ANKrepeats. MISCELLANEOUS:ConstructsencodingportionsofSNCAandSNCAIPco-transfectedinmammaliancellspromotecytosolicinclusionsresemblingtheLewybodiesofParkinsondisease.CoexpressionofSNCA,SNCAIP,andPARK2resultintheformationofLewybody-likeubiquitin-positivecytosolicinclusions.FamilialmutationsinPARK2disrupttheubiquitinationofSNCAIPandtheformationoftheubiquitin-positiveinclusions.TheseresultsprovideamolecularbasisfortheubiquitinationofLewybody-associatedproteinsandlinkPARK2andSNCAinacommonpathogenicmechanismthroughtheirinteractionwithSNCAIP.

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Millipore/AB5388 | Anti-Synphilin-1 Antibody, a.a. 829-847/AB5388/50 µL

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