| Immunogen | Peptidecorrespondingtoaminoacids1-19fromratSynaptotagminI(Accession#P21107). | 
| Epitope | luminalpart | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | RecognizesSynaptotagminI,luminalpart.Theepitopedoesnotsharehomologywithanyotherknownproteins. 
 SPECIESREACTIVITIES:Itisexpectedthattheantibodywillalsorecognizehuman.Otherspecieshavenotbeentested.
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| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThesynaptotagminsareintegralmembraneproteinsofsynapticvesiclesthoughttoserveasCa(2+)sensorsintheprocessofvesiculartraffickingandexocytosis.CalciumbindingtosynaptotagminIparticipatesintriggeringneurotransmitterreleaseatthesynapse(Fernandez-Chaconetal.,2001[PubMed11242035]).[suppliedbyOMIM] | 
| GeneSymbol | SYT1DKFZp781D2042SVP65SytISYTp65P65Synaptotagmin-1
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| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P21579#Mayhavearegulatoryroleinthemembraneinteractionsduringtraffickingofsynapticvesiclesattheactivezoneofthesynapse.Itbindsacidicphospholipidswithaspecificitythatrequiresthepresenceofbothanacidicheadgroupandadiacylbackbone.ACa(2+)-dependentinteractionbetweensynaptotagminandputativereceptorsforactivatedproteinkinaseChasalsobeenreported.ItcanbindtoatleastthreeadditionalproteinsinaCa(2+)-independentmanner;theseareneurexins,syntaxinandAP2. COFACTOR:Binds3calciumionspersubunit.TheionsareboundtotheC2domains(Bysimilarity).
 SIZE:422aminoacids;47573Da
 SUBUNIT:Homotetramer(Probable).InteractswithSTN2,SV2A,SV2B,SV2CandRIMS1.FormsacomplexwithSV2B,syntaxin1andSNAP25(Bysimilarity).
 SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesicle.Cytoplasmicvesicle,secretoryvesicle,chromaffingranule.Note=Synapticvesiclesandchromaffingranules.
 DOMAIN:SwissProt:P21579ThefirstC2domainmediatesCa(2+)-dependentphospholipidbinding.&ThesecondC2domainmediatesinteractionwithSV2AandSTN2(Bysimilarity).
 SIMILARITY:Belongstothesynaptotagminfamily.&Contains2C2domains.
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