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Millipore/AB5669 | Anti-Spinophilin Antibody/AB5669/100 µg

價格: ￥4188.00 市場價: 6980.00

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貨號: AB5669

品牌: Millipore

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Description
CatalogueNumber	AB5669
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-SpinophilinAntibody
AlternateNames	NeurABIn-II

ProductInformation
Format	AffinityPurified
Presentation	Affinitypurifiedimmunoglobulin.Liquidin0.02Mphosphatebuffercontaining0.25MNaCl,pH7.6with0.1%sodiumazide.

StorageandShippingInformation
StorageConditions	Maintainat2-8°Cinundilutedforupto6monthsafterdateofreceipt.

Applications
Application	Anti-SpinophilinAntibodydetectslevelofSpinophilin&hasbeenpublished&validatedforuseinWB.
KeyApplications	WesternBlotting
ApplicationNotes	Westernblot:0.05-0.1μg/mLusingECLonratbrainlysate.Reactswithabandof~140kDa. Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	SyntheticpeptidefromratSpinophilin.
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	Spinophilin
SpeciesReactivity	Rat
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_032595.3
EntrezGeneSummary	Spinophilinisaregulatorysubunitofproteinphosphatase-1catalyticsubunit(PP1;seeMIM176875)andishighlyenrichedindendriticspines,specializedprotrusionsfromdendriticshaftsthatreceivemostoftheexcitatoryinputinthecentralnervoussystem(Allenetal.,1997[PubMed9275233]).[suppliedbyOMIM]
GeneSymbol	PPP1R9B Spinophilin PPP1R9 Neurabin-2 PPP1R6 FLJ30345 spinophilin Neurabin-II SPINO
UniProtNumber	Q96SB3
UniProtSummary	FUNCTION:SwissProt:Q96SB3#Seemstoactasascaffoldproteininmultiplesignalingpathways.Modulatesexcitatorysynaptictransmissionanddendriticspinemorphology.Bindstoactinfilaments(F-actin)andshowscross-linkingactivity.BindsalongthesidesoftheF-actin.MayplayanimportantroleinlinkingtheactinCytoskeletontotheplasmamembraneatthesynapticjunction.Believedtotargetproteinphosphatase1/PP1todendriticspines,whicharerichinF-actin,andregulatesitsspecificitytowardionchannelsandothersubstrates,suchasAMPA-typeandNMDA-typeglutamatereceptors.PlaysaroleinregulationofG-proteincoupledreceptorsignaling,includingdopamineD2receptorsandalpha-adrenergicreceptors.MayestablishasignalingcomplexfordopaminergicneurotransmissionthroughD2receptorsbylinkingreceptorsdownstreamsignalingmoleculesandtheactincytoskeleton.BindstoADRA1BandRGS2andmediatesregulationofADRA1Bsignaling.MayconfertoRacsignalingspecificitybybindingtoboth,RacGEFsandRaceffectorproteins.Probablyregulatesp70S6kinaseactivitybyformingacomplexwithTIAM1(Bysimilarity). SIZE:815aminoacids;89192Da SUBUNIT:PossIBLyexistsasanhomodimer,homotrimeroranhomotetramer.InteractswithF-actin,PPP1CA,neurabin-1,TGN38andD(2)dopaminereceptor.InteractswithRGS1,RGS2,RGS4,RGS19andADRA1B,ADRA2A,ADRA2B,ADRA2C,CDKN2A,PPP1R2,RASGFR1andTIAM1. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Nucleus(Bysimilarity).Cellprojection,dendriticspine(Bysimilarity).Celljunction,synapse.Note=Enrichedatsynapseandcadherin-basedcell-celladhesionsites.Inneurons,bothcytosolicandmembrane-associated,andhighlyenrichedinthepost-synapticdensityapposedtoexitatorysynapses.ColocalizeswithPPP1R2atactin-richadherensjunctionsinepithelialcellsandindendriticspines(Bysimilarity). PTM:StimulationofD1(butnotD2)dopaminereceptorsinducesSer-94phosphorylation.DephosphorylationofSer-94ismediatedmainlybyPP1andtoalesserextentbyPP2A.PhosphorylationofspinophilindisruptsitsassociationwithF-actin,butdoesnotaffectitsbindingtoPP1(Bysimilarity). SIMILARITY:SwissProt:Q96SB3##Contains1PDZ(DHR)domain.

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Millipore/AB5669 | Anti-Spinophilin Antibody/AB5669/100 µg

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