| Immunogen | GSTfusionproteincorrespondingtoacytoplasmic,N-terminalpartofratormouseVAMP-2(AccessionnumbersQ64357,NP036795). | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | RecognizesVAMP-2(Vesicle-AssociatedMembraneProtein2,Synaptobrevin2).Theepitopedoesnotsharehomologywithanyotherknownproteins.
  SPECIESREACTIVITIES:Itisexpectedthattheantibodywillalsoreactwithhuman,Macacamultataandbovineduetosequencehomology(25/26).Otherspecieshavenotbeentested. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthevesicle-associatedmembraneprotein(VAMP)/synaptobrevinfamily.Synaptobrevins/VAMPs,syntaxins,andthe25-kDsynaptosomal-associatedproteinSNAP25arethemaincomponentsofaproteincomplexinvolvedinthedockingand/orfusionofsynapticvesicleswiththepresynapticmembrane.Thisgeneisthoughttoparticipateinneurotransmitterreleaseatastepbetweendockingandfusion.Theproteinformsastablecomplexwithsyntaxin,synaptosomal-associatedprotein,25kD,andsynaptotagmin.Italsoformsadistinctcomplexwithsynaptophysin.Itisalikelycandidategeneforfamilialinfantilemyasthenia(FIMG)becauseofitsmaplocationandbecauseitencodesasynapticvesicleproteinofthetypethathasbeenimplicatedinthepathogenesisofFIMG. | 
| GeneSymbol | - VAMP2
 - VAMP-2
 - FLJ11460
 - Synaptobrevin-2
 - SYB2
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P63027#Involvedinthetargetingand/orfusionoftransportvesiclestotheirtargetmembrane. SIZE:116aminoacids;12649Da SUBUNIT:InteractswithVAPAandVAPB. SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane;Single-passtypeIVmembraneprotein.Note=Neuronalsynapticvesicles. TISSUESPECIFICITY:Nervoussystemandskeletalmuscle. SIMILARITY:SwissProt:P63027##Belongstothesynaptobrevinfamily.&Contains1v-SNAREcoiled-coilhomologydomain. |