| Immunogen | Syntheticpeptidecorrespondingtoaminoacids108-127ofsolublecytoplasmichumanPGP9.5. | 
| Host | Rabbit | 
| Specificity | ProteinGeneProduct9.5(PGP9.5). | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | UCHL1isamemberofagenefamilywhoseproductshydrolyzesmallC-terminaladductsofubiquitintogeneratetheubiquitinmonomer.ExpressionofUCHL1ishighlyspecifictoneuronsandtocellsofthediffuseneuroendocrinesystemandtheirtumors.Itispresentinallneurons(Doranetal.,1983[PubMed6343558]).[suppliedbyOMIM] | 
| GeneSymbol | UCHL1PARK5UCH-L1Uch-L1PGP9.5EC3.4.19.12EC6.-.-.-
 | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P09936#Ubiquitin-proteinhydrolaseinvolvedbothintheprocessingofubiquitinprecursorsandofubiquitinatedproteins.ThisenzymeisathiolproteasethatrecognizesandhydrolyzesapeptidebondattheC-terminalglycineofubiquitin.Alsobindstofreemonoubiquitinandmaypreventitsdegradationinlysosomes.ThehomodimermayhaveATP-independentubiquitinligaseactivity. SIZE:223aminoacids;24824Da
 SUBUNIT:Homodimer.InteractswithSNCA(Bysimilarity).InteractswithCOPS5.
 SUBCELLULARLOCATION:Cytoplasm.
 TISSUESPECIFICITY:Foundinneuronalcellbodiesandprocessesthroughouttheneocortex(atproteinlevel).Expressedinneuronsandcellsofthediffuseneuroendocrinesystemandtheirtumors.Weaklyexpressedinovary.
 PTM:O-glycosylated(Bysimilarity).
 DISEASE:SwissProt:P09936#OxidationofMet-1,Met-6,Met-12,Met-124andMet-179tomethioninesulfoxide,andoxidationofCys-220tocysteinesulfonicacidhavebeenobservedinbrainsfromAlzheimerdisease(AD)andParkinsondisease(PD)patients.InAD,UCHL1wasfoundtobeassociatedwithneurofibrillarytangles.
 SIMILARITY:SwissProt:P09936##BelongstothepeptidaseC12family.
 MISCELLANEOUS:IncontrasttoUCHL3,doesnothydrolyzeapeptidebondattheC-terminalglycineofNEDD8.
 |