| Immunogen | Syntheticpeptide. | 
| Host | Rabbit | 
| Specificity | ReactswithSodiumPump(Na+pump(Na+-K+-ATPase))alpha2isoform.TheantibodydoesnotcrossreactwithotherNa+-K+-ATPasealphaisoforms. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | TheproteinencodedbythisgenebelongstothefamilyofP-typecationtransportATPases,andtothesubfamilyofNa+/K+-ATPases.Na+/K+-ATPaseisanintegralmembraneproteinresponsIBLeforestablishingandmaintainingtheelectRochemicalgrADIentsofNaandKionsacrosstheplasmamembrane.Thesegradientsareessentialforosmoregulation,forsodium-coupledtransportofavarietyoforganicandinorganicmolecules,andforelectricalexcitABIlityofnerveandmuscle.Thisenzymeiscomposedoftwosubunits,alargecatalyticsubunit(alpha)andasmallerglycoproteinsubunit(beta).ThecatalyticsubunitofNa+/K+-ATPaseisencodedbymultiplegenes.Thisgeneencodesanalpha2subunit. | 
| GeneSymbol | ATP1A2FHM2MGC59864KIAA0778MHP2+KNaEC3.6.3.9
 | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P50993#Thisisthecatalyticcomponentoftheactiveenzyme,whichcatalyzesthehydrolysisofATPcoupledwiththeexchangeofsodiumandpotassiumionsacrosstheplasmamembrane.Thisactioncreatestheelectrochemicalgradientofsodiumandpotassium,providingtheenergyforactivetransportofvariousnutrients. SIZE:1020aminoacids;112265Da
 SUBUNIT:Composedofthreesubunits:alpha(catalytic),betaandgamma.
 SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein.
 DISEASE:SwissProt:P50993#DefectsinATP1A2arethecauseoffamilialhemiplegicmigraine2(FHM2)[MIM:602481].Familialhemiplegicmigraineisarare,severe,autosomaldominantsubtypeofmigrainecharacterizedbyauraandsomehemiparesis.&DefectsinATP1A2areacauseofalternatinghemiplegiaofchildhood(AHC)[MIM:104290].AHCistypicallydistinguishedfromfamilialhemiplegicmigrainebyinfantileonsetofthesymptomsandhighprevalenceofassociatedneurologicaldeficitsthatbecomeincreasinglyobviouswithage.
 SIMILARITY:SwissProt:P50993##BelongstothecationtransportATPase(P-type)family.TypeIICsubfamily.
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