| Immunogen | SyntheticpeptideofaminoacidssurroundingthephosphoSerine549siteofratSynapsinI. | 
| Host | Rabbit | 
| Specificity | SynapsinI,phosphoSerine549.Theantibodyrecognizesaproteindoubletof~78kDacorrespondingtoSynapsinI,phosphoSerine549inlysatesfromratbrain.TheimmunolabelingiscompletelyeliminatedbytreatmentwithlamBDa-Ptase. | 
| SpeciesReactivity |  | 
| SpeciesReactivityNote | Theimmunogenhas100%homologywithhuman,mouse,non-humanprimate,bovineandcanine. | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneisamemberofthesynapsingenefamily.Synapsinsencodeneuronalphosphoproteinswhichassociatewiththecytoplasmicsurfaceofsynapticvesicles.Familymembersarecharacterizedbycommonproteindomains,andtheyareimplicatedinsynaptogenesisandthemodulationofneurotransmitterrelease,suggestingapotentialroleinseveralneuropsychiatricdiseases.Thismemberofthesynapsinfamilyplaysaroleinregulationofaxonogenesisandsynaptogenesis.Theproteinencodedservesasasubstrateforseveraldifferentproteinkinasesandphosphorylationmayfunctionintheregulationofthisproteininthenerveterminal.MutationsinthisgenemaybeassociatedwithX-linkeddisorderswithprimaryneuronaldegenerationsuchasRettsyndrome.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified. | 
| GeneSymbol | - SYN1
 - SYN1a
 - Synapsin-1
 - SYNI
 - SYN1b
 
  | 
| Modifications |  | 
| PurificationMethod | ImmunoAffinityPurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P17600#Neuronalphosphoproteinthatcoatssynapticvesicles,bindstotheCytoskeleton,andisbelievedtofunctionintheregulationofneurotransmitterrelease.ThecomplexformedwithNOS1andCAPONproteinsisnecessaryforspecificnitric-oxidfunctionsatapresynapticlevel. SIZE:705aminoacids;74111Da SUBUNIT:Homodimer.InteractswithCAPON.FormsaternarycomplexwithNOS1(Bysimilarity). SUBCELLULARLOCATION:Celljunction,synapse. PTM:Substrateofatleastfourdifferentproteinkinases.Itisprobablethatphosphorylationplaysaroleintheregulationofsynapsin-1inthenerveterminal.PhosphorylateduponDNAdamage,probablybyATMorATR. DISEASE:SwissProt:P17600#DefectsinSYN1areacauseofX-linkedrecessiveepilepsyassociatedwithvariablelearningdisABIlitiesandbehaviordisorders[MIM:300491]. SIMILARITY:SwissProt:P17600##Belongstothesynapsinfamily. |