| Immunogen | SyntheticpeptidefrommouseQKI-7. | 
| Host | Rabbit | 
| Specificity | QKI-7(QuakingProtein).Theantibodyrecognizesthe~42kDaprotein. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | QKIbelongstoafamilyofRNA-bindingproteinsthathaveanHNRNPK(MIM600712)homology(KH)domainembeddedina200-aminoacidregioncalledtheGSGdomain.OthermembersofthisfamilyincludeSAM68(KHDRBS1;MIM602489)andSF1(MIM601516)(ChenandRichard,1998[PubMed9671495]).[suppliedbyOMIM] | 
| GeneSymbol | QKIDKFZp586I0923HqkQK3QKHKQHqkI
 | 
| PurificationMethod | Serum | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q96PU8#RNA-bindingproteinthatplaysacentralroleinmyelinization.Bindstothe5"-NACUAAY-N(1,20)-UAAY-3"RNAcoresequence.Actsbyregulatingpre-mRNAsplicing,mRNAexport,mRNAstabilityandproteintranslation.RequiredtoprotectandpromotestabilityofmRNAssuchasMBPandCDKN1Bwhichpromotesoligodendrocytedifferentiation.ParticipatesinmRNAtransportbyregulatingthenuclearexportofMBPmRNA.AlsoinvolvedinregulationofmRNAsplicingofMAGpre-mRNA.Actsasatranslationalrepressor(Bysimilarity). SIZE:341aminoacids;37671Da
 SUBUNIT:Homodimer.DoesnotrequireRNAtohomodimerize.AbletoheterodimerizewithBICC1(Bysimilarity).
 SUBCELLULARLOCATION:Nucleus(Bysimilarity).Cytoplasm(Bysimilarity).
 TISSUESPECIFICITY:Expressedinthefrontalcortexofbrain.
 PTM:MethylatedbyPRMT1(Bysimilarity).&TyrosinephosphorylatedatitsC-terminus,probablybyFYN.PhosphorylationleadstodecreasedmRNA-bindingaffinity,affectingtransportand/orstabilizationofMBPmRNA(Bysimilarity).
 DISEASE:SwissProt:Q96PU8#Mayplayaroleingeneticsusceptibilitytoschizophrenia.QKIlevelsofsomeisoformssuchasisoform6,arefrequentlydown-regulatedinschizophrenicpatients.&DeletionoftheQKIgenemayplayaroleinastrocytictumors.
 SIMILARITY:SwissProt:Q96PU8##Contains1KHdomain.
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