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Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg

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貨號: ABE208

品牌: Millipore

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Description
CatalogueNumber	ABE208
Replaces	04-1002
Description	Anti-β-CateninAntibody
AlternateNames	catenin(cadherin-associatedprotein),beta1,88kDa catenin(cadherin-associatedprotein),beta1(88kD)
BackgroundInformation	β-cateninisthefoundingmemberoftheβ-cateninfamily.Thisproteiniscomprisedof12ARMrepeatsandisconsideredtohavedualfunctiondependingonitslocalization.Cytoplasmicβ-cateninisacriticalcomponentofE-cadherin/cateningadhesioncomplexesandisinvolvedinregulatingcadherin-dependentcell-cellinteractions.Whenlocalizedtothenucleus,β-cateninservesaregulatoryrolebybindingwithtranscriptionfactorsfromtheTCF/LEFfamily,activatingtranscription.Expressionofβ-cateninhasbeenreportedinavarietyofhairfolliclecellssuchascellsfoundintheinnerandouterportionsoftherootsheaths,andthebasalandperipheralmatrixcells.Ithasalsobeenobservedincolontissue.Defectsinexpressionhavebeenlinkedtothedevelopmentofseveraltumorsandcancerssuchas;colorectalcancer(CRC),medulloblastoma(MDB),ovariancancer(OC),andpilomatrixoma(PTR).

ProductInformation
Format	AffinityPurified
Control	A431celllysate
Presentation	Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	Anti-β-CateninAntibodyisaRabbitPolyclonalAntibodyfordetectionofβ-Cateninalsoknownascatenin(cadherin-associatedprotein)beta1(88kD)&hasbeenvalidatedinWB,ICC&IP.
KeyApplications	WesternBlotting Immunocytochemistry Immunoprecipitation
ApplicationNotes	ImmunoprecipitationAnalysis:10μgfromarepresentativelotimmunoprecipitatedβ-CateninfromA431lysate. ImmunocytochemistryAnalysis:1:500dilutionfromarepresentativelotdetectedβ-CatenininNIH/3T3andA431cells.

BIOLOGicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingtotheconsensusGSK3phosphorylationsiteofhumanβ-Catenin.
Epitope	ConsensusGSK3phosphorylationsiteofhumanβ-Catenin
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	Antibodyrecognizesβ-CateninattheN-terminus.
SpeciesReactivity	Human Mouse Rat Horse Ox
SpeciesReactivityNote	Demonstratedtoreactwithhuman,mouse,andrat.Predictedtoreactwithequineandoxbasedon100%sequencehomology.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_001895
EntrezGeneSummary	Theproteinencodedbythisgeneispartofacomplexofproteinsthatconstituteadherensjunctions(AJs).AJsarenecessaryforthecreationandmaintenanceofepithelialcelllayersbyregulatingcellgrowthandadhesionbetweencells.TheencodedproteinalsoanchorstheactinCytoskeletonandmayberesponsIBLefortransmittingthecontactinhibitionsignalthatcausescellstostopdividingoncetheepithelialsheetiscomplete.Finally,thisproteinbindstotheproductoftheAPCgene,whichismutatedinadenomatouspolyposisofthecolon.Mutationsinthisgeneareacauseofcolorectalcancer(CRC),pilomatrixoma(PTR),medulloblastoma(MDB),andovariancancer.Threetranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene.
GeneSymbol	CTNNB1 CTNNB Beta-catenin PRO2286
PurificationMethod	AffinityPurfied
UniProtNumber	P35222
UniProtSummary	FUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway. SIZE:781aminoacids;85497Da SUBUNIT:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.ThestABIlizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossiblyalsoRUVBL1andDUPLIN.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1binding(Bysimilarity).InteractswiththePDZdomainofTAX1BP3;thisinteractioninhibitsthetranscriptionalactivityofCTNNB1(Bysimilarity).InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2.InteractswithSLC30A9(Bysimilarity). SUBCELLULARLOCATION:Cytoplasm.Nucleus.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2promotesnucleartranslocation. TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon. PTM:PhosphorylationbyGSK3BrequirespriorphosphorylationofSer-45byanotherkinase.PhosphorylationproceedsthenfromThr-41toSer-37andSer-33.&EGFstimulatestyrosinephosphorylation.PhosphorylationonTyr-654decreasesCDH1bindingandenhancesTBPbinding.&UbiquitinatedbyaE3ubiquitinligasecomplexcontainingUBE2D1,SIAH1,CACYBP/SIP,SKP1A,APCandTBL1X(Probable).Itsubiquitinationleadstoitssubsequentproteasomaldegradation. DISEASE:ActivatingmutationsinCTNNB1haveoncogenicactivityresultingintumordevelopment.Somaticmutationsarefoundinvarioustumortypes,includingcoloncancers,ovarianandprostatecarcinomas,hepatoblastoma(HB),hepatocellularcarcinoma(HCC).HBsaremalignantembryonaltumorsmainlyaffectingyoungchildreninthefirstthreeyearsoflife.&DefectsinCTNNB1areacauseofpilomatrixoma(PTR)[MIM:132600];acommonbenignskintumor.&DefectsinCTNNB1areacauseofmedulloblastoma(MDB)[MIM:155255].MDBisamalignant,invasiveembryonaltumorofthecerebellumwithapreferentialmanifestationinchildren.&AchromosomalrearrangementinvolvingCTNNB1maybeacauseofsalivaryglandpleiomorphicadenomas(PA)[181030].Pleiomorphicadenomasarethemostcommonbenignepithelialtumorsofthesalivarygland.Translocationt(3;8)(p21;q12)withPLAG1." SIMILARITY:Belongstothebeta-cateninfamily.&Contains12ARMrepeats.
MolecularWeight	~86kDaobserved.

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Millipore/ABE208 | Anti-β-Catenin Antibody/ABE208/100 µg

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