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Millipore/ABN78 | Anti-NeuN Antibody (rabbit)/ABN78/100 µg

價格: ￥4188.00 市場價: 6980.00

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貨號: ABN78

品牌: Millipore

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Description
CatalogueNumber	ABN78
Description	Anti-NeuNAntibody(rabbit)
AlternateNames	RNAbindingproteinfox-1homolog3 Fox-1homologC Fox-3 Hexaribonucleotide-bindingprotein3 NeuN Neuronalnuclei
BackgroundInformation	RNAbindingproteinfox-1homolog3(UniProtQ8BIF2;alsoknownasFox-1homologC,Fox-3,Hexaribonucleotide-bindingprotein3,NeuN,Neuronalnuclei)isencodedbytheRbfox3(alsoknownasD11Bwg0517e,Hrnbp3)gene(GeneID52897)inmurinespecies.TheRNA-bindingFox(Rbfox)familyofsplicingfactorsiscomprisedofthreemembers,Rbfox1(Fox-1orA2BP1),Rbfox2(Fox-2orRBM9),andRbfox3(Fox-3,HRNBP3orNeuN).Rbfoxproteinsregulatesplicingofmanyneuronaltranscripts(pre-mRNAs)bybindingthesequence(U)GCAUGinintronsflankingalternativeexons.A(U)GCAUGmotifthatliesdownstreamofthealternativeexongenerallypromotesRbfox-dependentexoninclusion,whereasanupstreammotifwillusuallyrepressexoninclusion.OriginallycharacterizedasaMarkerofpost-mitoticneuronsandnamedneuronalnuclei(NeuN),Rbfox3playsaroleinpromotingneuronaldifferentiationthroughalternativesplicingofNumbpre-mRNAduringbraindevelopment.Rbfox3-knockoutinmiceisreportedtoresultindefectivehippocampalgeneexpression,defectsinsynaptictransmissionandplasticityinthedentategyrus,aswellasincreasedseizuresusceptibilityanddecreasedanxiety-relatedbehaviors.Likewise,humanRBFOX3genemutationshavebeenlinkedtoneurodevelopmentaldelay,cognitiveimpairments,autisticfeatures,andepilepsy.

ProductInformation
Format	AffinityPurified
Control	Mousebrainnuclearextract
Presentation	Purifiedrabbitpolyclonalantibodyinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	Anti-NeuN(rabbit)Antibody,Cat.No.ABN78,isahighlyspecificrabbitpolyclonalantibodythattargetsNeuNandhasbeentestedinImmunocytochemistry,Immunofluorescence,Immunohistochemistry,andWesternBlotting.
KeyApplications	Immunocytochemistry Immunohistochemistry Immunofluorescence WesternBlotting
ApplicationNotes	ImmunocytochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedNeuNinculturedembryonicE18rathippocampusneurons. ImmunohistochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedNeuN-positiveneuronsinhuman(cerebellumandcerebralcortex)andmouse(hippocampus)braintissuesections. ImmunocytochemistryAnalysis:Arepresentativelotsimmunostained4%paraformaldehyde-fixedneuronsisolatedfromsnailbrain(Nikoli?,L.,etal.(2013).J.Exp.Biol.216(Pt18):3531-3541). ImmunofluorescenceAnalysis:RepresentativelotsdetectedNeuN-positiveneuronsinfrozenbrainsectionsfrom4%paraformaldehyde-perfusedmice(Cherry,J.D.,etal.(2015).J.Neuroinflammation.12:203;Huang,B.,etal.(2015).Neuron.85(6):1212-1226;Ataka,K.,etal.(2013).PLoSOne.8(11):e81744). ImmunofluorescenceAnalysis:ArepresentativelotsdetectedNeuN-positiveneuronsinformalin-fixedandparaffin-embeddedamyotrophiclateralsclerosis(ALS)humanbraintissuesections(Fratta,P.,etal.(2015).Neurobiol.Aging.36(1):546.e1-7). ImmunohistochemistryAnalysis:ArepresentativelotdetectedNeuN-positiveneuronsinratbraintissuesections(Mendon?a,M.C.,etal.(2013).Toxins.5(12):2572-2588). WesternBlottingAnalysis:RepresentativelotdetectedNeuNinmouseandratbraintissuelysates(Huang,B.,etal.(2015).Neuron.85(6):1212-1226;Mendon?a,M.C.,etal.(2013).Toxins.5(12):2572-2588). ThisrabbitpolyclonalantibodyisalsoavaiableasAlexaFluor?488(ABN78A4),biotin(ABN78B),andCy3(ABN78C3)conjugatesforimmunocytochemistry,immunofluorescence,immunohistochemistryapplications.

BIOLOGicalInformation
Immunogen	GST-taggedrecombinantmouseNeuNN-terrminalfragment.
Epitope	N-terminus
Concentration	Pleaserefertolotspecificdatasheet.
Host	Rabbit
Specificity	ThisrabbitpolyclonalantibodytargetsNeuNN-terminalregionthatendsatthestartofRNArecognitionmotif(RRM).Targetregionispresentinallhuman,mouse,andratsplicedisoformsreportedbyUniProt(A6NFN3,Q8BIF2,D4A2H6,A0A0G2K2J4).
SpeciesReactivity	Human Mouse Rat Snail
SpeciesReactivityNote	Human,Mouse,Rat,Snail.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_001034256
GeneSymbol	Rbfox3 D11Bwg0517e Hrnbp3
PurificationMethod	AffinityPurfied
UniProtNumber	Q8BIF2
MolecularWeight	~48/42kDaobserved.33.87/35.12kDa(humanisoform1/2),40.61/39.05/35.64/34.07/35.63kDa(mouseisoform1/2/3/4/5),40.59kDa(rat;UniProtD4A2H6),34.05kDa(rat;UniProtA0A0G2K2J4)calculated.Uncharacterizedbandsmaybeobservedinsomelysate(s).

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Millipore/ABN78 | Anti-NeuN Antibody (rabbit)/ABN78/100 µg

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