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Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg

價格: ￥3324.00 市場價: 5540.00

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貨號: ABS150

品牌: Millipore

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Description
CatalogueNumber	ABS150
Description	Anti-phospho-PDGFRα(Tyr754)Antibody
AlternateNames	Platelet-derivedgrowthfactorreceptoralpha PDGF-R-alpha PDGFR-alpha Alphaplatelet-derivedgrowthfactorreceptor Alpha-typeplatelet-derivedgrowthfactorreceptor CD140antigen-likefamilymemberA CD140aantigen Platelet-derivedgrowthfactoralphareceptor Platelet-derivedgrowthfactorreceptor2 Shortname=PDGFR-2 CD_antigen=CD140a
BackgroundInformation	PDGFRα(platelet-derivedgrowthfactor;Alpha-typeplatelet-derivedgrowthfactorreceptor;CD140antigen-likefamilymemberA)isaubiquitousreceptortyrosinekinase.Itisactivatedbythebindingofhomo-orheterodimersofPDGFA,PDGFBorPDGFC.Uponligandbinding,PDGFRαdimerizesastwoalphaortwobetasubunitsdependingonthecellularcontext,andisautophosphorylatedatmultipletyrosineresidues.Phosphorylatedtyrosineresiduesinteractwithdifferenttargetstomediatecellproliferation,migration,andsurvival.PhosphorylationatTyrosine754inducesheterodimerizationandallowsPDGFRαtointeractwithPTPN11.Inaddition,PDGRαregulatesapoptosisbymultiplesignalingpathwaysthatconvergeonproapoptoticproteinssuchasBAD.Forinstance,PDGFRαsignalingdeactivatesBADbyinductionofPI3K/Akt;PLC-gamma/PKC/Bcl-2;andRas/Raf/Erksignalingpathways.DefectivePDGFRαhasbeenimplicatedin?hypereosinophilicsyndromeandgastrointestinalstromaltumor.

ProductInformation
Format	AffinityPurified
Control	UntreatedandPDGFtreatedNIH/3T3celllysates
Presentation	Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	Detectphospho-PDGFRα(Tyr754)usingthisAnti-phospho-PDGFRα(Tyr754)AntibodyvalidatedforuseinWesternBlotting.
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingtohumanPDGFRαphosphorylatedat(Tyr754).
Epitope	Phosphorylated(Tyr754)
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	ThisantibodyrecognizesPDGFRαphosphorylatedat(Tyr754).
SpeciesReactivity	Mouse Human Rat Bovine
SpeciesReactivityNote	DemonstratedtoreactwithMouse.PredictedtoreactwithHuman,Rat,andBovinebasedon100%sequencehomology.Otherhomologies:XenopusandChicken(91%sequencehomology).
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_006197
EntrezGeneSummary	Thisgeneencodesacellsurfacetyrosinekinasereceptorformembersoftheplatelet-derivedgrowthfactorfamily.Thesegrowthfactorsaremitogensforcellsofmesenchymalorigin.Theidentityofthegrowthfactorboundtoareceptormonomerdetermineswhetherthefunctionalreceptorisahomodimeroraheterodimer,composedofbothplatelet-derivedgrowthfactorreceptoralphaandbetapolypeptides.Studiesinknockoutmice,wherehomozygosityislethal,indicatethatthealphaformoftheplatelet-derivedgrowthfactorreceptorisparticularlyimportantforkidneydevelopmentsincemiceheterozygousforthereceptorexhibitdefectivekidneyphenotypes.[providedbyRefSeq,Jul2008].
GeneSymbol	PDGFRA PDGFR2 RHEPDGFRA
Modifications	Phosphorylation
PurificationMethod	AffinityPurfied
UniProtNumber	P16234
UniProtSummary	FUNCTION:Tyrosine-proteinkinasethatactsasacell-surfacereceptorforPDGFA,PDGFBandPDGFCandplaysanessentialroleintheregulationofembryonicdevelopment,cellproliferation,survivalandchemotaxis.Dependingonthecontext,promotesorinhibitscellproliferationandcellmigration.Playsanimportantroleinthedifferentiationofbonemarrow-derivedmesenchymalstemcells.Requiredfornormalskeletondevelopmentandcephalicclosureduringembryonicdevelopment.Requiredfornormaldevelopmentofthemucosaliningthegastrointestinaltract,andforrecruitmentofmesenchymalcellsandnormaldevelopmentofintestinalvilli.Playsaroleincellmigrationandchemotaxisinwoundhealing.Playsaroleinplateletactivation,secretionofagoNISTsfromplateletgranules,andinthrombin-inducedplateletaggregation.Bindingofitscognateligands-homodimericPDGFA,homodimericPDGFB,heterodimersformedbyPDGFAandPDGFBorhomodimericPDGFC-leadstotheactivationofseveralsignalingcascades;theresponsedependsonthenatureoftheboundligandandismodulatedbytheformationofheterodimersbetweenPDGFRAandPDGFRB.PhosphorylatesPIK3R1,PLCG1,andPTPN11.ActivationofPLCG1leadstotheproductionofthecellularsignalingmoleculesdiacylglycerolandinositol-1,4,5-trisphosphate,mobilizationofcytosolicCa2+andtheactivationofproteinkinaseC.PhosphorylatesPIK3R1,theregulatorysubunitofphosphatidylinositol3-kinase,andtherebymediatesactivationoftheAKT1signalingpathway.MediatesactivationofHRASandoftheMAPkinasesMAPK1/ERK2and/orMAPK3/ERK1.PromotesactivationofSTATfamilymembersSTAT1,STAT3andSTAT5Aand/orSTAT5B.Receptorsignalingisdown-regulatedbyproteinphosphatasesthatdephosphorylatethereceptoranditsdown-streameffectors,andbyrapidinternalizationoftheactivatedreceptor. CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. ENZYMEREGULATION:Presentinaninactiveconformationintheabsenceofboundligand.BindingofPDGFAand/orPDGFBleadstodimerizationandactivationbyautophosphorylationontyrosineresidues.Inhibitedbyimatinib,nilotinibandsorafenib. SUBUNITSTRUCTURE:InteractswithhomodimericPDGFA,PDGFBandPDGFC,andwithheterodimersformedbyPDGFAandPDGFB.Monomerintheabsenceofboundligand.InteractionwithdimericPDGFA,PDGFBand/orPDGFCleadstoreceptordimerization,wherebothPDGFRAhomodimersandheterodimerswithPDGFRBareobserved.Interacts(tyrosinephosphorylated)withSHB(viaSH2domain)(Bysimilarity).Interacts(tyrosinephosphorylated)withSHF(viaSH2domain).Interacts(tyrosinephosphorylated)withSRC(viaSH2domain).Interacts(tyrosinephosphorylated)withPIK3R1.Interacts(tyrosinephosphorylated)withPLCG1(viaSH2domain).Interacts(tyrosinephosphorylated)withCRK,GRB2andGRB7.SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note:Theactivatedreceptorisrapidlyinternalizedanddegraded. TISSUESPECIFICITY:Detectedinplatelets(atproteinlevel).Widelyexpressed.Detectedinbrain,fibroblasts,smoothmuscle,heart,andembryo.Expressedinprimaryandmetastaticcolontumorsandinnormalcolontissue. PTM:N-glycosylated. Ubiquitinated,leADIngtoitsdegradationProbable. Autophosphorylatedontyrosineresiduesuponligandbinding.Autophosphorylationoccursintrans,i.e.onesubunitofthedimericreceptorphosphorylatestyrosineresiduesontheothersubunit.PhosphorylationatTyr-731andTyr-742isimportantforinteractionwithPIK3R1.PhosphorylationatTyr-720andTyr-754isimportantforinteractionwithPTPN11.PhosphorylationatTyr-762isimportantforinteractionwithCRK.PhosphorylationatTyr-572andTyr-574isimportantforinteractionwithSRCandSRCfamilymembers.PhosphorylationatTyr-988andTyr-1018isimportantforinteractionwithPLCG1. INVOLVEMENTINDISEASE:Note=AchromosomalaberrationinvolvingPDGFRAisfoundinsomecasesofhypereosinophilicsyndrome.Interstitialchromosomaldeletiondel4(q12q12)causesthefusionofFIP1L1andPDGFRA(FIP1L1-PDGFRA).Mutationsthatcauseoverexpressionand/orconstitutiveactivationofPDGFRAmaybeacauseofhypereosinophilicsyndrome. DefectsinPDGFRAareacauseofgastrointestinalstromaltumor(GIST)[MIM:606764].Note=MutationsthatcauseconstitutiveactivationofPDGFRAmaybeacauseofgastrointestinalstromaltumor(GIST). SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily. Contains5Ig-likeC2-type(immunoglobulin-like)domains. Contains1proteinkinasedomain. SEQUENCECAUTION:ThesequenceAAP69563.1differsfromthatshown.Reason:Erroneousinitiation.TranslationN-terminallyshortened.
MolecularWeight	~180kDaobserved

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Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg

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