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Millipore/ABS44 | Anti-MAPK 1/2 Antibody/ABS44/100 µg

價格: ￥3324.00 市場價: 5540.00

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貨號: ABS44

品牌: Millipore

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Description
CatalogueNumber	ABS44
Replaces	06-182
Description	Anti-MAPK1/2Antibody
AlternateNames	ERK-1 ERT2 Extracellularsignal-regulatedkinase1 Insulin-stimulatedMAP2kinase MAPkinase3 MAPkinaseisoformp44 MAPK3 Microtubule-associatedprotein2kinase Mitogen-activatedproteinkinase3 MNK1 p44-ERK1 p44-MAPK ERK-2 ERT1 Extracellularsignal-regulatedkinase2 MAPkinase1 MAPkinase2 MAPkinaseisoformp42 MAPK1 MAPK2 Mitogen-activatedproteinkinase1 Mitogen-activatedproteinkinase2 p42-MAPK
BackgroundInformation	Mitogen-activatedproteinkinase3(EC2.7.11.24;UniProtP21708;alsoknownasERK-1,ERT2,Extracellularsignal-regulatedkinase1,Insulin-stimulatedMAP2kinase,MAPkinase3,MAPkinaseisoformp44,MAPK3,Microtubule-associatedprotein2kinase,MNK1,p44-ERK1,p44-MAPK)isencodedbytheMapk3(alsoknownasErk1,Prkm3)gene(GeneID50689)inratspecies.ERK1(a.k.a.MAPK3)andERK2(a.k.a.MAPK1orMAPK2)arerelatedserine/threoninekinasesoftheRas-Raf-MEK-ERKsignalingpathway.ERK1/2areactivatedbyMEK1/2-catalyzedphosphorylationattheirconservedThr-Glu-Tyr(TEY)dualphosphorylationmotif,firstattheTyrresidue(human/ratERK1Tyr204/Tyr203,human/ratERK2Tyr187/Tyr183)andthenattheThrresidue(human/ratERK1Thr202/Thr201,human/ratERK2Thr185/Thr181).ERK1/2areproline-directedkinasesthatpreferentiallycatalyzethephosphorylationofPro-Xxx-Ser/Thr-Prosequencemotifinhundredsofcytoplasmicandnuclearsubstrates,includingtranscriptionfactorssuchasEts,Elk,andc-Fos.Besidesthisprimarystructurerequirement,manyERK1/2substratespossessaD-dockingsiteand/oranF-dockingsite.Avarietyofscaffoldproteins,includingKSR1/2,IQGAP1,MP1,andβ-Arrestin1/2,alsoparticipateintheregulationofERK1/2MAPkinasecascade.Ras-Raf-MEK-ERKsignalingactivityisupregulatedinaboutone-thirdofallhumancancers,andtargetedinhibitionagainstcomponentsofthissignalingpathwayrepresentsapopularanticancerstrategy.

ProductInformation
Format	Purified
Control	A431celllysate
Presentation	Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	DetectMAPK3/MAPK1(ERK1/ERK2)usingthisAnti-MAPK1/2AntibodyvalidatedforuseinImmunocytochemistry,Immunoprecipitation,andWesternBlotting.
KeyApplications	WesternBlotting Immunoprecipitation Immunocytochemistry
ApplicationNotes	WesternBlottingAnalysis:0.5μg/mLfromarepresentativelotdetectedMAPK3/MAPK1(ERK1/ERK2)inBALB/3T3,A431,andL6celllysates. WesternBlotting(SNAPID)Analysis:1-2μg/mLfromarepresentativelotdetectedMAPK3/MAPK1(ERK1/ERK2)inBALB/3T3,A431,andL6celllysates. ImmunocytochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedMAPK3/MAPK1(ERK1/ERK2)inNIH/3T3,A431,HeLa,andC2C12cells.

BIOLOGicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingtotheC-terminalsequenceofratMAPK3(ERK-1).
Epitope	C-terminal
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	ThisantibodyrecognizesMAPK3/MAPK1(ERK1/ERK2)C-terminalsequence.
SpeciesReactivity	Rat Mouse Human
SpeciesReactivityNote	Reactswithhuman,mouse,andrat.Expectedtoreactwithbovineandcaninebasedon94%sequencehomology.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_059043
GeneSymbol	Erk1 Erk2 Mapk Mapk1 Mapk3 Prkm1 Prkm3
PurificationMethod	ProteinApurfied.
UniProtNumber	P21708
MolecularWeight	~44/42kDaobserved.41.26/36.30kDa(humanMAPK1isoform1/2),41.14kDa(ratMAPK1),41.14kDa(mouseMAPK1),43.00/38.14kDa(humanMAPK3isoform1/2),42.95/45.64kDa(ratMAPK3isoform1/2),42.93kDa(mouseMAPK3)calculated(Met1removed).TargetsequenceisnotpresentinhumanMAPK3splicedisoform3(ERK1b).

PhysicochemicalInformation

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MaterialsInformation

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Millipore/ABS44 | Anti-MAPK 1/2 Antibody/ABS44/100 µg

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