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Millipore/ABS82 | Anti-VEGF Antibody/ABS82/100 µg

價格: ￥3444.00 市場價: 5740.00

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貨號: ABS82

品牌: Millipore

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Description
CatalogueNumber	ABS82
Replaces	07-1376
Description	Anti-VEGFAntibody
AlternateNames	vascularendothelialgrowthfactorA vascularendothelialgrowthfactor VascularpermeABIlityfactor vascularendothelialgrowthfactorisoformVEGF
BackgroundInformation	VEGF(Vascularendothelialgrowthfactor,VEGFA,VEGF-A),adimericligand,isamongthemostpotentangiogenicmitogens.VEGFissecretedbytumorcellsandothercellsexposedtohypoxia.VEGFisahighlyspecificmitogenforvascularendothelialcells.SevenVEGFisoforms(a,b,c,d,e,f,g)aregeneratedasaresultofalternativesplicingfromasingleVEGFgene.ThemostcommonlystudiedisoformsareVEGF121,VEGF165,andVEGF189(f,dandb,respectively)AllsevenisoformsdifferintheirmolecularmassandinBIOLOGicalpropertiessuchastheirabilitytobindtocell-surfaceheparan-sulfateproteoglycans.TheexpressionofVEGFispotentiatedandissecretedbytumorcellsinresponsetohypoxia,byactivatedoncogenes,andbyavarietyofcytokines.VEGFinducesangiogenesisaswellaspermeabilizationofbloodvessels,andplaysacentralroleintheregulationofvasculogenesis.VEGFexpressioncorrelatestothedegreeoftumorvascularizationandwithincreasedmetastaticrisk.Additionally,VEGFinducesendothelialcellproliferation,promotescellmigration,andinhibitsapoptosis.Consequently,inhibitionofVEGFsignalingabrogatesthedevelopmentofawidevarietyoftumors.

ProductInformation
Format	AffinityPurified
Control	HuVeccelllysate
Presentation	Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	DetectVEGFusingthisAnti-VEGFAntibodyvalidatedforuseinWB,IH(P).
KeyApplications	WesternBlotting Immunohistochemistry(Paraffin)
ApplicationNotes	ImmunohistochemistryAnalysis:1:400dilutionfromapreviouslotdetectedVEGFinnormalhumanplacentalvillitissue.

BiologicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingtohumanVEGFattheN-terminus.
Epitope	N-terminus
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	ThisantibodyrecognizesVEGFattheN-terminus.
SpeciesReactivity	Human Mouse Rat Primate
SpeciesReactivityNote	Demonstratedtoreactwithhuman,mouse,andrat.Predictedtoreactwithprimatebasedon100%sequencehomology. Otherhomologies:Bovine(85%sequencehomology).Rat(70%sequencehomology).Mouse(65%sequencehomology).
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_001020537
EntrezGeneSummary	ThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms.[providedbyRefSeq].
GeneSymbol	VPF VEGF-A MVCD VEGF VEGA
PurificationMethod	AffinityPurfied
UniProtNumber	P15692
UniProtSummary	FUNCTION:Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145. SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity). SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin. ALTERNATIVEPRODUCTS:10namedisoforms[FASTA]producedbyalternativesplicing.
MolecularWeight	~55kDaobserved.UniProtKB/Swiss-ProtP15692(VEGFA_HUMAN)entrydescribes13isoformsproducedbyalternativepromoterusage,alternativesplicingandalternativeinitiation:Isoform1at27.042kDa,Isoform2at25.173kDa,Isoform3at24.422kDa,Isoform4at22.314kDa,Isoform5at20.218kDa,Isoform6at20.064kDa,Isoform7at22.259kDa,Isoform8at17.219kDa,Isoform9at15.981kDa,Isoform10at40.738kDa,Isoform11at35.643kDa,Isoform12at43.597kDa,Isoform13at45.467kDa.

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Millipore/ABS82 | Anti-VEGF Antibody/ABS82/100 µg

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