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Millipore/CC126 | Caspase 1, recombinant human active/CC126/25 units

價格: ￥3204.00 市場價: 5340.00

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貨號: CC126

品牌: Millipore

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Description
CatalogueNumber	CC126
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Caspase1,recombinanthumanactive
Overview	Caspase-1(alsoknownasICE,Interleukin-1beta-ConvertingEnzyme)istheprototypicalmemberofthecaspasefamilyofcysteineproteases.Caspase-1existsincellsasaninactive45kDapro-enzyme.Thepro-enzymeismaturedbyproteolysistoyieldlarge(20kD)andsmall(10kD)subunits.Theactiveenzymeisaheterotetramerconsistingoftwolargeandtwosmallsubunits.Todatethemechanismofregulationofcaspase-1activationiscomplexandpoorlyunderstood.InTHP-1cells,alargeproportionofthecaspase-1ispresentintheinactivepro-enzymeform. Theactiverecombinanthumancaspase-1wasexpressedinE.coli.Theexpressedcaspase-1spontaneouslyundergoesautoprocessingtoyieldthesubunitscharacteristicofthenativeenzyme.Therecombinantcaspase-1preferentiallycleavesthesubstratesconsistingofconsensussequenceYVAD(e.g.,YVAD-AFCandYVAD-pNA).Therecombinantenzymecanalsobeusedasapositivecontrolincaspaseassaysorindeterminingthespecificityofcaspasesubstrates. Recommendedusage:0.5-1unitforfluorometriccaspaseassaysand2-4unitsforcolorimetriccaspaseassays.Optimalworkingdilutionsmustbedeterminedbyenduser.

ProductInformation
Presentation	Lyophilized.Reconstitutein25μLPBScontaining15%glycerol.

StorageandShippingInformation
StorageConditions	Maintainunopenedandrehydratedproductat-70°Cinundiluted,freeze-thawprotected,tightlysealedaliquots.Avoidrepeatedfreeze/thawcycles.Productstablefor6monthsfromdateofpurchasedifhandledappropriately.

Applications
KeyApplications	ActivityAssay

BIOLOGicalInformation
Purity	Partiallypurifiedrecombinantcaspase3withafulllengthHIS-6-tag.Approximately10-20%caspase1protein.TheremainderisE.Coliproteins.Approximately0.8-2mgtotalprotein/Uofactivity;E.Coliproteinshavenoreactivity.
EntrezGeneNumber	NM_001223.3 NM_033292.2 NM_033293.2 NM_033294.2 NM_033295.2
EntrezGeneSummary	Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproduce2subunits,largeandsmall,thatdimerizetoformtheactiveenzyme.ThisgenewasidentifiedbyitsABIlitytoproteolyticallycleaveandactivatetheinactiveprecursorofinterleukin-1,acytokineinvolvedintheprocessessuchasinflammation,septicshock,andwoundhealing.Thisgenehasbeenshowntoinducecellapoptosisandmayfunctioninvariousdevelopmentalstages.StudiesofasimilargeneinmousesuggestaroleinthepathogenesisofHuntingtondisease.Alternativesplicingofthisgeneresultsinfivetranscriptvariantsencodingdistinctisoforms.
GeneSymbol	CASP1 IL1BCE P45 IL-1BC IL1BC p45 IL1B-convertase CASP-1 ICE EC3.4.22.36[Contains:Caspase-1subunitp20 Caspase-1subunitp10].
UniProtNumber	P29466
UniProtSummary	FUNCTION:SwissProt:P29466#ThiolproteasethatcleavesIL-1betabetweenanAspandanAla,releasingthematurecytokinewhichisinvolvedinavarietyofinflammatoryprocesses.Importantfordefenseagainstpathogens.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs).Canalsopromoteapoptosis. SIZE:404aminoacids;45159Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya20kDa(p20)anda10kDa(p10)subunit.Thep20subunitcanalsoformaheterodimerwiththeepsilonisoformwhichthenhasaninhibitoryeffect.Maybeacomponentoftheinflammasome,aproteincomplexwhichalsoincludesPYCARD,CARD8andNALP2andwhosefunctionwouldbetheactivationofproinflammatorycaspases. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Expressedinlargeramountsinspleenandlung.Detectedinliver,heart,smallintestine,colon,thymus,prostate,skeletalmuscle,peripheralbloodleukocytes,kidneyandtestis.Noexpressioninthebrain. PTM:Thetwosubunitsarederivedfromtheprecursorsequencebyanautocatalyticmechanism. SIMILARITY:SwissProt:P29466##BelongstothepeptidaseC14family.&Contains1CARDdomain.

PhysicochemicalInformation

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Millipore/CC126 | Caspase 1, recombinant human active/CC126/25 units

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