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Millipore/FCABS319PE | Milli-Mark Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT -PE/FCABS319PE/100 tests

價格: ￥3204.00 市場價: 5340.00

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貨號: FCABS319PE

品牌: Millipore

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Description
CatalogueNumber	FCABS319PE
TradeName	Milli-Mark
Description	Milli-MarkAnti-MAPKinase1/2(Erk1/2)Antibody,CT-PE
BackgroundInformation	Theextracellularsignal-regulatedkinases1and2(ERK1andERK2),alsocalledp44andp42MAPkinases,aremembersoftheMitogenActivatedProteinKinase(MAPK)familyofproteinsfoundinalleukaryotes.Becausethe44kDaERK1andthe42kDaERK2arehighlyhomologousandbothfunctioninthesameproteinkinasecascade,thetwoproteinsareoftenreferredtocollectivelyasERK1/2orp44/p42MAPkinase.TheERK1/2signalingcascadehasbeenshowntobeacriticalregulatorofcelldifferentiation,cellphysiologyandneuronalfunction.AberrantcontrolofERK1/2activityhasbeenimplicatedinavarietyofpathologicalconditions,includingcancerandautoimmunediseases,andefficientstudymethodsareindemand.

ProductInformation
Format	Phycoerythrin
Control	A431cells
Presentation	PurifiedrabbitpolyclonalIgGconjugatedtoPEinPBSwith0.1%sodiumazideand15mg/mLBSA.

StorageandShippingInformation
StorageConditions	Maintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.

Applications
Application	ThisMilli-MarkAnti-MAPKinase1/2(Erk1/2)Antibody,CT-PEisvalidatedforuseinFCforthedetectionofMAPKinase1/2(Erk1/2).
KeyApplications	FlowCytometry

BIOLOGicalInformation
Immunogen	35residuesyntheticpeptidecorrespondingtotheC-terminusofratMAPKinase2/Erk2.
Host	Rabbit
Specificity	AntibodyrecognizesMAPK1/Erk1andMAPK2/Erk2
Isotype	IgG
SpeciesReactivity	Avian
SpeciesReactivityNote	TestedandpassedonHuman.Unconjugatedversion(Cat.No.06-182)isknowntoreactwithAvian,Mouse,Rat,Sheep,Xenopus,Echinoderms.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_002736
EntrezGeneSummary	TheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
GeneSymbol	MAPK1 p38 ERK P42MAPK ERK2 p40 PRKM1 p41mapk PRKM2 MAPK2 p42-MAPK p41 ERK-2 ERT1
PurificationMethod	AntigenAffinity
UniProtNumber	P28482
UniProtSummary	FUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4). COFACTOR:Magnesium(Bysimilarity). SIZE:360aminoacids;41390Da SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4. DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases. PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme. SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
MolecularWeight	41.4kDaCalculated

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Millipore/FCABS319PE | Milli-Mark Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT -PE/FCABS319PE/100 tests

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