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Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests

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貨號: FCMAB100P

品牌: Millipore

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Description
CatalogueNumber	FCMAB100P
TradeName	Milli-Mark
Description	Milli-MarkAnti-Phospho-Erk1/2Antibody(Thr202/Tyr204,Thr185/Tyr187)-PE
AlternateNames	Erk1 Erk2 p44-MAPK p42-MAPK MAPK2 PRKM2 p41mapk PRKM1 p44 ERK2 P42MAPK ERK p42 MAPK1 ERT1 ERT2 Mitogen-activatedproteinkinase MAPKinase2 MAPKianse1 MAPK
BackgroundInformation	Erk(Extracellularsignal-RelatedKinase)isafamilyoftwo,highlyhomologousproteinsdenotedasErk1(p44,MAPK3)andErk2(p42,MAPK1)thatbothfunctioninthesamepathway.ThetwoproteinsareoftenreferredtocollectivelyasErk1/2orp44/p42MAPkinase.TheErkpathwayisconsideredtheclassical,canonicalMAPK(Mitogen-ActivatedProteinKinase)signalingpathway.Itisanevolutionarilyconservedpathwaythatcontrolsandisacriticalregulatorofthegrowthandsurvivalthroughthepromotionofcellproliferationandthepreventionofapoptosis.Erkisinvolvedinthecontrolofmanyfundamentalcellularprocessesincludingcellproliferation,survival,differentiation,apoptosis,motilityandmetabolism.Erkisactivatedbygrowthfactorstimulationofreceptortyrosinekinases(RTKs),GPCR,and/orintegrinstimulation.ThisactivatestheRas-Raf-MEK-Erkpathwaythatresultsinthephosphorylation/activationofErk1/2(p44/p42)ontheTxYmotif(Thr202/Tyr204andThr185/Tyr187forErk1&Erk2,respectively).

ProductInformation
Format	PE
Control	JurkatCells
Presentation	PurifiedRabbitmonoclonalsupernatantconjugatedtophycoerythrininbuffercontainingPBSwith0.05%sodiumazide

StorageandShippingInformation
StorageConditions	Stablefor6monthsat2-8°Cfromdateofreceipt.Protectfromlight.

Applications
Application	ThisMilli-MarkPhospho-Erk1/2antibodyisvalidatedforuseinFlow&WBforthedetectionoftheMilli-MarkPhospho-Erk1/2protein.
KeyApplications	FlowCytometry WesternBlotting

BIOLOGicalInformation
Immunogen	PhosphorylatedrecombinantpeptidecorrespondingtoaminoacidssurroundingthepTEpYmotifintheactivationloopofhumanphospho-Erk1/2,inwhichtheThrandTyrresiduesarephosphorylated
Epitope	PhosphorylatedThr185/PhosphorylatedTyr187
Clone	AW39R
Host	Rabbit
Specificity	AntibodyrecognizesRecognizesErk1&2onlywhenduallyphosphorylatedonitsTxYactivationmotif.
Isotype	IgG
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	TestedandpassedonHuman.basedon100%sequencehomology.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_002736.3
EntrezGeneSummary	TheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
GeneSymbol	Erk1 Erk2 p44-MAPK p42-MAPK MAPK2 PRKM2 p41mapk PRKM1 p44 ERK2 P42MAPK ERK p42 MAPK1 ERT1 ERT2 Mitogen-activatedproteinkinase MAPKinase2 MAPKinase1 MAPK
Modifications	Phosphorylation
PurificationMethod	ProteinAPurfied
UniProtNumber	P28482
UniProtSummary	FUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4). COFACTOR:Magnesium(Bysimilarity). SIZE:360aminoacids;41390Da SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4. DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases. PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme. SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
MolecularWeight	42kDaand44kDaObserved

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Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests

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