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Millipore/FCMAB120P | Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2/FCMAB120P/100 tests

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貨號: FCMAB120P

品牌: Millipore

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Description
CatalogueNumber	FCMAB120P
TradeName	Milli-Mark
Description	Milli-MarkAnti-Beta-catenin-PEAntibody,clone7F7.2
AlternateNames	BetaCatenin Catenin(cadherin-associatedprotein),beta1
BackgroundInformation	Cateninsareproteinsfoundincomplexeswithcadherincelladhesionmoleculesofanimalcells.Thefirsttwocateninsthatwereidentifiedbecameknownasα-cateninandβ-catenin.α-Catenincanbindtoβ-cateninandcanalsobindactin.β-cateninbindsthecytoplasmicdomainofsomecadherins.Whenβ-cateninwassequenceditwasfoundtobeamemberofthearmADIllofamilyofproteins.Theseproteinshavemultiplecopiesoftheso-calledarmadillorepeatdomainwhichisspecializedforprotein-proteinbinding.Anincreaseinβ-cateninproductionhasbeennotedinthosepeoplewhohaveBasalCellCarcinomaandleadstotheincreaseinproliferationofrelatedtumors.Whenβ-cateninisnotassociatedwithcadherinsandα-catenin,itcaninteractwithotherproteinssuchasCateninBetaInteractingProtein1(ICAT)andadenomatosispolyposiscoli(APC).Recentevidencesuggeststhatβ-cateninplaysanimportantroleinvariousaspectsofliverBIOLOGyincludingliverdevelopment(bothembryonicandpostnatal),liverregenerationfollowingpartialhepatectomy,HGF-inducedhepatomegaly,liverzonation,andpathogenesisoflivercancer.

ProductInformation
Format	Phycoerythrin
Control	ATCCL-cells.
Presentation	PurifiedmousemonoclonalIgG1κconjugatedtoPEinPBSwith0.1%sodiumazideand15mg/mLBSA.

StorageandShippingInformation
StorageConditions	Maintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.

Applications
Application	ThisMilli-MarkAnti-Beta-cateninAntibody,clone7F7.2isvalidatedforuseinFCforthedetectionofBeta-catenin.
KeyApplications	FlowCytometry

BiologicalInformation
Immunogen	Fulllength,GST-taggedrecombinantbetacatenin.
Clone	7F7.2
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	AntibodyrecognizesBeta-catenin.
Isotype	IgG1κ
SpeciesReactivity	Mouse
SpeciesReactivityNote	TestedandpassedonMouse.UnconjugatedAbpartnumber04-958alsoreactsagainsthumanandrat.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_001895
EntrezGeneSummary	Beta-cateninisanadherensjunctionprotein.Adherensjunctions(AJs;alsocalledthezonulaadherens)arecriticalfortheestablishmentandmaintenanceofepitheliallayers,suchasthoseliningorgansurfaces.AJsmediateadhesionbetweencells,communicateasignalthatneighboringcellsarepresent,andanchortheactinCytoskeleton.Inservingtheseroles,AJsregulatenormalcellgrowthandbehavior.Atseveralstagesofembryogenesis,woundhealing,andtumorcellmetastasis,cellsformandleaveepithelia.Thisprocess,whichinvolvesthedisruptionandreestablishmentofepithelialcell-cellcontacts,mayberegulatedbythedisassemblyandassemblyofAJs.AJsmayalsofunctioninthetransmissionofthe"contactinhibition"signal,whichinstructscellstostopdividingonceanepithelialsheetiscomplete.[suppliedbyOMIM]
GeneSymbol	CTNNB CTNNB1 FLJ25606 FLJ37923 DKFZp686D02253
PurificationMethod	ProteinGPurified
UniProtNumber	P35222
UniProtSummary	FUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway. SUBUNIT:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.ThestABIlizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossIBLyalsoRUVBL1andDUPLIN.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1binding(Bysimilarity).InteractswiththePDZdomainofTAX1BP3;thisinteractioninhibitsthetranscriptionalactivityofCTNNB1(Bysimilarity).InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2andMUC1.InteractswithSLC30A9.InteractswithXIRP1(Bysimilarity). SUBCELLULARLOCATION:Cytoplasm.Nucleus.Cytoplasm,cytoskeleton.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2andMUC1promotesnucleartranslocation. TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon.
MolecularWeight	92kDaObserved

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Millipore/FCMAB120P | Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2/FCMAB120P/100 tests

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