Properties:
| RelatedCategories | Analytical/Chromatography,GEHealthcareLifeSciencesProteinSamplePreparationFormats,HiTrap&PD-10Cartridges,HiTrapSystem/syringe,MolecularBIOLOGy, |
| shelflife | Pleasebeawarethisproductmaybeshipped90daysbeforetheexpirationdate.Formoreinformationonthebatchspecificexpirationdate,pleasecontacttechnicalservice. |
| packaging | packof5×1 mL |
| mfr.no. | GEHealthcare,11-0034-93 |
| parameter | flowrate |
| | <4ml/minflowrate(1)Thepressureoverthepackedbedvariesdependingonarangeofparameterssuchasthecharacteristicsofthechromatographymediumandthecolumntubingused.) |
| | 42psi |
| bedsize | 7 mm×25 mm |
| bedvolume | 1 mL |
| columnI.D. | 7 mm |
| matrix | highlycross-linkedagarose |
| avg.part.size | 85 μm(d??visthemedianparticlesizeofthecumulativevolumedistribution) |
| cleaning | 2-13.7(pHbelow3issometimesrequiredtoelutestronglyboundIgGspecies.However,proteinligandsmayhydrolyzeatverylowpH.) |
| workingrange | 3-12(pHbelow3issometimesrequiredtoelutestronglyboundIgGspecies.However,proteinligandsmayhydrolyzeatverylowpH.) |
| capacity | ≥30 mgbindingcapacity(humanlgG/mlat2.4minresidencetime)(Determinedat10%breakthroughbyfrontalanalysisatamobilephasevelocityof500cm/hinacolumnwithabedheightof20cm.) |
| suitABIlity | suitableforbioprocessmedium |
| storagetemp. | 2-8°C |
Description:
AnalysisNote
ToviewtheCertificateofAnalysisforthisproduct,pleasevisitwww.geLifesciences.com
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LegalInformation
FreeMabSelectSuReLigand
"MabSelectSuReLigandRestrictedLicense"and"Cys-rProteinALigandRestrictedLicense"areprotectedbythefollowingpatentsandequivalentpatentsandpatentapplicationsinothercountries:US6,399,750andEP1123389.Afree,non-transferablelimitedlicensetousethisproductforinternalanalyticalpurposesonlyaccompaniesthepurchaseoftheproductfromaGEHealthcarecompanyanditslicenseddistributors.AnyotherusewillrequireaseparatelicensefromaGEHealthcarecompany.
HiTrapisaregisteredtrademarkofGEHealthcare
MabSelectisatrademarkofGEHealthcare
SuReisatrademarkofGEHealthcare
FeaturesandBenefits
• WithstandsrigorousCIPandsanitizationprocedureswith0.1to0.5MNaOH.
• Novelliganddesigngivesenhancedproteaseresistanceresultinginlowerligandleakage.
• OrientedcouplingofrecombinantProteinAtothematrixviaanengineeredC-terminalcysteineenhancesIgGbindingcapacity.
• Fewerregulatoryconcernsduetothetotalabsenceofmammaliancultureintheligandproductionandpurification.
• PrepackedHiTrap®columnsforprocessdevelopment,screeningofpurificationconditions,andsmall-scalepurificationofMabs.
Generaldescription
HiTrap®MabSelect™SuRe™columnsareprepackedwithMabSelect™SuRe,aBioProcessmediumforpurificationofmonoclonalantibodiesfromlargesamplevolumes.Thenovelalkali-tolerantrecombinantProteinAligandallowcleaning-in-place(CIP).
HiTrap®MabSelect™columnsareprepackedwithMabSelect™abioprocessmediumforcapuringofMabsfromlargesamplevolumes.
Safety:
Symbol

GHS02
Precautionarystatements
P210-P370+P378
RIDADR
UN1170-class3-PG3-Ethanol,solution