This antibody pair set comes with matched antibody pair to detect and quantify protein level of human ACTN4.
Reactivity:
Human
Quality Control Testing:
Standard curve using recombinant protein ( H00000081-Q01 ) as an analyte.Sandwich ELISA detection sensitivity ranging from 0.1 ng/ml to 100 ng/ml.
Supplied Product:
Antibody pair set content: 1. Capture antibody: mouse monoclonal anti-ACTN4, IgG2a Kappa (100 ug) 2. Detection antibody: biotinylated mouse monoclonal anti-ACTN4, IgG2a (50 ug) *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
Storage Instruction:
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
MSDS:
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Interspecies Antigen Sequence:
Mouse (98%); Rat (98%)
Datasheet:
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Applications
ELISA Pair (Recombinant protein)
Protocol Download
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ELISA Pair (Recombinant protein)
Gene Information
Entrez GeneID:
81
Gene Name:
ACTN4
Gene Alias:
ACTININ-4,DKFZp686K23158,FSGS,FSGS1
Gene Description:
actinin, alpha 4
Omim ID:
603278, 604638
Gene Ontology:
Hyperlink
Gene Summary:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins.Alpha actinin is an actin-binding protein with multiple roles in different cell types.In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane.In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
Other Designations:
actinin alpha4 isoform
Interactome
Gene Pathway
Adherens junction
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Focal adhesion
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Systemic lupus erythematosus
Tight junction
Related Disease
Alport syndrome
Cardiovascular Diseases
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Edema
Genetic Predisposition to Disease
Glomerulosclerosis, Focal Segmental
Kidney Diseases
Proteinuria
Related Product
DF0001
ACTN4 DNA Probe
DF0002
ACTN4/CEN19p FISH Probe (Orange/Green)
DH0003
Anti-ACTN4 monoclonal antibody
DI0119
ACTN4 & CTNNB1 Protein Protein Interaction Antibody Pair
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特別 提示
Sandwich ELISA detection sensitivity ranging from 0.1 ng/ml to 100 ng/ml.
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