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            當前位置 : Millipore >>> Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg
            Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg
            • Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg

            Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg

            價格: ¥3948.00 市場價: 6580.00

            貨號: MAB1149
            品牌: Millipore
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              • Description
                CatalogueNumberMAB1149
                BrandFamilyChemicon®
                TradeName
                • Chemicon
                DescriptionAnti-Tie-2Antibody,extracellular,clone4G8HE
                OverviewPurity:Greaterthan95%bySDS-PAGE.0.22micronsterilefiltered.
                AlternateNames
                • Angiopoietin-1Receptor
                • p140TEK
                BackgroundInformationTie-2isanendothelial-specificreceptortyrosinekinaseandareceptorforangiopoietin1.ItisatypeImembraneproteinthatisexpressedpredominantlyintheendotheliumofactivelygrowingbloodvesselsandmayrepresenttheearliestmammalianendothelialcelllineageMarker.Tie-2islikelyinvolvedintheregulationofendothelialcellproliferationanddifferentiationandmaydirectthespecialorientationofendothelialcellsduringtheformationofbloodvessels.
                ProductInformation
                FormatPurified
                Control
                • POSITIVECONTROL:placentaandlungtissue.
                PresentationImmunoglobulinpurifiedbyproteinGaffinitychromatography.LiquidinPBS,pH7.4,containing0.05%Bronidoxasapreservative.
                StorageandShippingInformation
                StorageConditionsMaintainrefrigeratedat2-8°Cinundilutedaliquotsforupto12months.
                Applications
                ApplicationAnti-Tie-2Antibody,extracellular,clone4G8HEdetectslevelofTie-2&hasbeenpublished&validatedforuseinELISA,FC&WB.
                KeyApplications
                • ELISA
                • FlowCytometry
                • WesternBlotting
                ApplicationNotesWesternblot:10μg/mL.Recognizesabandmigratingatapproximately140kDacorrespondingtomouseTie-2.

                FACS:10μg/mL

                ELISA

                Optimalworkingdilutionsmustbedeterminedbyenduser.
                BIOLOGicalInformation
                ImmunogenTheextracellulardomainofmouseTie-2receptor.
                Epitopeextracellular
                Clone4G8HE
                ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
                HostRat
                SpecificityRecognizesmouseTie-2Receptor.
                IsotypeIgG1
                SpeciesReactivity
                • Mouse
                AntibodyTypeMonoclonalAntibody
                EntrezGeneNumber
                EntrezGeneSummaryTheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase.
                GeneSymbol
                • TEK
                • CD202B
                • TIE2
                • VMCM1
                • VMCM
                • hTIE2
                • CD202b
                • TIE-2
                • EC2.7.10.1
                UniProtNumber
                UniProtSummaryFUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation.
                SIZE:1124aminoacids;125811Da
                SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
                TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney.
                DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels.
                SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain.
                PhysicochemicalInformation
                Dimensions
                MaterialsInformation
                MaterialsInformation
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