| Immunogen | TcellenrichedsplenocytesfromB10mice | 
| Clone | M1/70.15.1 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rat | 
| Specificity | RecognizesthemurinealphaMintegrinchain,whichexistsasaheterodimerwiththebeta2integrin(Springer,1979;Springer,1990).Theantibodystainspolymorphonuclearcells,monocytesandNKcells.Variableactivityisreportedwithtissuemacrophages.M1/70.15.1blocksiC3bbindingtoitsreceptor(Beller,1982). | 
| Isotype | IgG2b | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThisgeneencodestheintegrinalphaMchain.Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.ThisI-domaincontainingalphaintegrincombineswiththebeta2chain(ITGB2)toformaleukocyte-specificintegrinreferredtoasmacrophagereceptor1("Mac-1"),orinactivated-C3b(iC3b)receptor3("CR3").ThealphaMbeta2integrinisimportantintheadherenceofneutrophilsandmonocytestostimulatedendothelium,andalsointhephagocytosisofcomplementcoatedparticles.SomeintegrinalphaMproteinscontainaninsertedaminoacid(Q,betweenAApositions499and500)resultingfroma3bpshiftinaspliceacceptorthatinsertsthecodonCAG;receptorswithorwithouttheextraaminoacidarefunctionallyindistinguishable | 
| GeneSymbol | ITGAMMO1ACD11bMAC1ACD11BMAC-1CR3AMGC117044
 | 
| PurificationMethod | ProteinGPurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P11215#Integrinalpha-M/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.ItisidenticalwithCR-3,thereceptorfortheiC3bfragmentofthethirdcomplementcomponent.ItprobablyrecognizestheR-G-DpeptideinC3b.Integrinalpha-M/beta-2isalsoareceptorforfibrinogen,factorXandICAM1.ItrecognizesP1andP2peptidesoffibrinogengammachain. SIZE:1152aminoacids;127179Da
 SUBUNIT:Heterodimerofanalphaandabetasubunit.Alpha-Massociateswithbeta-2.
 SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
 TISSUESPECIFICITY:Predominantlyexpressedinmonocytesandgranulocytes.
 DOMAIN:SwissProt:P11215TheintegrinI-domain(insert)isaVWFAdomain.IntegrinswithI-domainsdonotundergoproteasecleavage.
 SIMILARITY:Belongstotheintegrinalphachainfamily.&Contains7FG-GAPrepeats.&Contains1VWFAdomain.
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