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Millipore/MAB1407P | Anti-Macrophages/Granulocytes Antibody, clone OX-41/MAB1407P/100 µg

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貨號: MAB1407P

品牌: Millipore

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Description
CatalogueNumber	MAB1407P
Replaces	MAB1407
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-Macrophages/GranulocytesAntibody,cloneOX-41
AlternateNames	CD172antigen-likefamilymemberA CD172aantigen InhibitoryreceptorSHPS-1 Macrophagefusionreceptor MyD-1antigen SHPsubstrate1 SHPsubstrate-1 Signal-regulatoryproteinalpha-1 signal-regulatoryproteinalpha
BackgroundInformation	MacrophagesandgranulocytesexpressSignalregulatoryprotein(SIRP),whichisatransmembraneglycoproteininvolvedinthedownregulationoftyrosinekinasereceptorsignaltransductioninducedbycelladhesion,growthfactorsorinsulin.Theyareimmunoglobulin-likecellsurfacereceptorforCD47.ByCD47bindingthereisanegativeregulationofphagocytosis,mastcellactivationanddendriticcellactivationthatpreventsmaturationofimmaturedendriticcellsandinhibitscytokineproductionbymaturedendriticcells.

ProductInformation
Format	AffinityPurified
Control	Macrophages,monocytes,lymphoidorgans.
Presentation	PurifiedmousemonoclonalIgG2ainbuffercontaining0.09%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor6monthsat2-8°Cinundilutedaliquotsfromdateofreceipt.

Applications
Application	ThisAnti-Macrophages/GranulocytesAntibody,cloneOX-41isvalidatedforuseinFC,IC,IH,IH(P),WBforthedetectionofMacrophages/Granulocytes.
KeyApplications	FlowCytometry Immunocytochemistry Immunohistochemistry Immunohistochemistry(Paraffin) WesternBlotting
ApplicationNotes	Immunohistochemistry: FrozensectionsandFormalinfixed,paraffinembeddedtissuesections(requirestrypsinorpronasepre-treatment). WesternBlotting: Apreviouslotofthisantibodywasusedinwesternblot. Flowcytometry: 1:100-1:200ofapreviouslotwasused.(Use10μLofworkingdilutionfor10^6cellsin100μL). Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	Ratperitonealmacrophages.
Clone	OX-41
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	MAB1407PrecognizesratSIRP(Signalregulatoryprotein),whichisexpressedselectivelybymyeloidcellsandbyneurons.ThismonoclonalbindstoadifferentepitopeonSIRPthanED9.ItdoesnotblocktheinteractionofCD172aandCD47. Labelsmostmacrophagesincludingresidentperitoneal,alveolarandactivatedmacrophages.Recognitionofothermacrophagesislimitedtoonlyoccasionalkupffercells.Inadditionitlabelsgranulocytesandapopulationofdendriticcells.Italsolabelsbrainextensively.
Isotype	IgG2a
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Human.Expectedtocross-reactwithratandmouse.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_001035111
EntrezGeneSummary	Theproteinencodedbythisgeneisamemberofthesignal-regulatory-protein(SIRP)family,andalsobelongstotheimmunoglobulinsuperfamily.SIRPfamilymembersarereceptor-typetransmembraneglycoproteinsknowntobeinvolvedinthenegativeregulationofreceptortyrosinekinase-coupledsignalingprocesses.Thisproteincanbephosphorylatedbytyrosinekinases.Thephospho-tyrosineresiduesofthisPTPhavebeenshowntorecruitSH2domaincontainingtyrosinephosphatases(PTP),andserveassubstratesofPTPs.Thisproteinwasfoundtoparticipateinsignaltransductionmediatedbyvariousgrowthfactorreceptors.CD47hasbeendemonstratedtobealigandforthisreceptorprotein.ThisgeneanditsproductshareveryhighsimilaritywithseveralothermembersoftheSIRPfamily.Theserelatedgenesarelocatedincloseproximitytoeachotheronchromosome20p13.Multiplealternativelysplicedtranscriptvariantshavebeendeterminedforthisgene.[providedbyRefSeq]
GeneSymbol	CD172a SIRPA SIRPalpha2 BIT SHPS1 MFR SIRP p84 SHPS-1 Sirp-alpha-1 CD172A Sirp-alpha-2 SIRP-ALPHA-1 PTPNS1 SIRPalpha P84 Bit MYD1 MYD-1
PurificationMethod	ImmunoAffinityPurified
UniProtNumber	P78324
UniProtSummary	FUNCTION:SwissProt:P78324#Immunoglobulin-likecellsurfacereceptorforCD47.ActsasdockingproteinandinducestranslocationofPTPN6,PTPN11andotherbindingpartnersfromthecytosoltotheplasmamembrane.Supportsadhesionofcerebellarneurons,neuriteoutgrowthandglialcellattachment.Mayplayakeyroleinintracellularsignalingduringsynaptogenesisandinsynapticfunction(Bysimilarity).Involvedinthenegativeregulationofreceptortyrosinekinase-coupledcellularresponsesinducedbycelladhesion,growthfactorsorinsulin.Mediatesnegativeregulationofphagocytosis,mastcellactivationanddendriticcellactivation.CD47bindingpreventsmaturationofimmaturedendriticcellsandinhibitscytokineproductionbymaturedendriticcells. SIZE:503aminoacids;54813Da SUBUNIT:BindsPTPN11whentyrosine-phosphorylated,exceptinmacrophages,whereitprimarilybindsPTPN6.BindsGRB2invitro.BindsFGR(Bysimilarity).BindsJAK2irrespectiveofitsphosphorylationstatusandformsastablecomplex.BindsSCAP1and/orSCAP2.TheresultingcomplexrecruitsFYB.BindsPTK2B. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Ubiquitous.Highlyexpressedinbrain.Detectedonmyeloidcells,butnotT-cells.Detectedatlowerlevelsinheart,placenta,lung,testis,ovary,colon,liver,smallintestine,prostate,spleen,kidney,skeletalmuscleandpancreas. PTM:N-glycosylated.&PhosphorylatedontyrosineresiduesinresponsetostimulationwithEGF,growthhormone,insulinandPDGF.DephosphorylatedbyPTPN11. SIMILARITY:SwissProt:P78324##Contains2Ig-likeC1-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain
MolecularWeight	56kDa

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Millipore/MAB1407P | Anti-Macrophages/Granulocytes Antibody, clone OX-41/MAB1407P/100 µg

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