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Millipore/MAB1592 | Anti-Neurofilament H & M Antibody, phosphorylated, clone NP1/MAB1592/100 µL

價格: ￥4188.00 市場價: 6980.00

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貨號: MAB1592

品牌: Millipore

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Description
CatalogueNumber	MAB1592
Replaces	04-1061
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-NeurofilamentH&MAntibody,phosphorylated,cloneNP1
BackgroundInformation	NeurofilamentsareatypeofintermediatefilamentthatserveasmajorelementsoftheCytoskeletonsupportingtheaxoncytoplasm.Theyarethemostabundantfibrillarcomponentsoftheaxon,beingonaverage3-10timesmorefrequentthanaxonalmicrotubules.Neurofilaments(10nmindia.)arebuiltfromthreeintertwinedprotofibrilswhicharethemselvescomposedoftwotetramericprotofilamentcomplexsofmonomericproteins.Theneurofilamenttripletproteins(68/70,160,and200kDa)occurinboththecentralandperipheralnervoussystemandareusuallyneuronspecific.The68/70kDaNF-Lproteincanself-assembleintoafilamentousstructure,howeverthe160kDaNF-Mand200kDaNF-Hproteinsrequirethepresenceofthe68/70kDaNF-Lproteintoco-assemble.Neuromas,ganglioneuromas,gangliogliomas,ganglioneuroblastomasandneuroblastomasstainpositivelyforneurofilaments.Althoughtypicallyrestrictedtoneurons,neurofilamentshavebeendetectedinparagangliomasandadrenalandextra-adrenalpheochromocytomas.Carcinoids,neuroendocrinecarcinomasoftheskin,andoatcellcarcinomasofthelungalsoexpressneurofilaments.FormoreneurofilamentinformationseeNervousSystemCellTypeSpecificMarkerchartonlineundertheCHEMICONTechnicalSupportsection.

ProductInformation
Format	Ascites
Presentation	Liquid.Containsnopreservative.

StorageandShippingInformation
StorageConditions	Maintainat-20°Cinundilutedaliquotsforuptosixmonths.Avoidrepeatedfreeze/thawcycles.

Applications
Application	DetectNeurofilamentH&MusingthisAnti-NeurofilamentH&MAntibody,phosphorylated,cloneNP1validatedforuseinELISA,FC,RIA,WB,IC,IH(P).
KeyApplications	ELISA FlowCytometry RADIoimmunoassay WesternBlotting Immunocytochemistry Immunohistochemistry(Paraffin)
ApplicationNotes	Westernblot:recognizes,200kDa,and150kDaNF-HandNF-Mbandsprimarily.Stainingisremovedwithphosphatasetreatment.BecauseNF-Lalsocontainslysine-serinePO4sites,NP1maycrossreactwithNF-Laswell,butthishasnotbesubstantiatedintraditionalwesterns. Immunohistochemistry.Worksonparaffinembedded,formalinfixedandfrozenacteonefixedtissuesections.1:50-1:500forimmunofluorescence. ImmunocytochemistryonPC12,TERA-2andotherneuronallines. FACSELISA/RIA Optimalworkingdilutionsmustbedeterminedbyenduser.

BIOLOGicalInformation
Immunogen	Bovineneurofilaments
Epitope	phosphorylated
Clone	NP1
Host	Mouse
Specificity	RecognizestheKSPrepeatsofthephosphorylatedformsofneurofilament-M(NF-M)andneurofilament-H(NF-H),becauseNF-LdoescontainafewoftheseLysine-serine-PO4-prolinerepeatssomecrossreactivitytoNF-Lmaybeseenatveryhighantibodyconcentrations.
Isotype	IgG1
SpeciesReactivity	Bovine Chicken Human Rat
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_021076.2
GeneSymbol	NEFH NFH NF-H KIAA0845
Modifications	Phosphorylation
UniProtNumber	P12036 P07197
UniProtSummary	FUNCTION:SwissProt:P12036#Neurofilamentsusuallycontainthreeintermediatefilamentproteins:L,M,andHwhichareinvolvedinthemaintenanceofneuronalcaliber.NF-HhasanimportantfunctioninmatureaxonsthatisnotsubservedbythetwosmallerNFproteins. SIZE:1026aminoacids;112480Da PTM:ThereareanumberofrepeatsofthetripeptideK-S-P,NFHisphosphorylatedonanumberoftheserinesinthismotif.ItisthoughtthatphosphorylationofNFHresultsintheformationofinterfilamentcrossbridgesthatareimportantinthemaintenanceofaxonalcaliber.&Phosphorylationseemstoplayamajorroleinthefunctioningofthelargerneurofilamentpolypeptides(NF-MandNF-H),thelevelsofphosphorylationbeingaltereddevelopmentallyandcoincidentwithachangeintheneurofilamentfunction. DISEASE:SwissProt:P12036#DefectsinNEFHareacauseofsusceptibilitytoamyotrophiclateralsclerosis(ALS)[MIM:105400].ALSisaneurodegenerativedisorderaffectingupperandlowermotorneurons,andresultinginfatalparalysis.Sensoryabnormalitiesareabsent.Deathusuallyoccurswithin2to5years.Theetiologyislikelytobemultifactorial,involvingbothgeneticandenvironmentalfactors. SIMILARITY:SwissProt:P12036##Belongstotheintermediatefilamentfamily.

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Millipore/MAB1592 | Anti-Neurofilament H & M Antibody, phosphorylated, clone NP1/MAB1592/100 µL

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