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Millipore/MAB1904 | Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2/MAB1904/100 µg

價格: ￥3948.00 市場價: 6580.00

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貨號: MAB1904

品牌: Millipore

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Description
CatalogueNumber	MAB1904
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-Laminin-1A&BchainsAntibody,crossregion,cloneAL-2
AlternateNames	lamininalpha1 lamininbeta1
BackgroundInformation	Lamininsaresecretedglycoproteinsincorporatedintocell-associatedextracellularmatricesandanintegralpartofthestructuralscaffoldinginmostanimaltissues.Thelamininproteinismadeupofthreepolypeptidechains;α,βandγ,accountingforitsflexibilityinconnectingvariousmolecules.Whenoriginallycharacterized,laminin-1cloneAL-2reactedwithEngelbreth-Holm-Swarm(EHS)mouselamininA&Bchainsonthelongarmnearthecrossregion,(Skubitz,1987).Morerecently,investigations,(Schèele,2006)haveshownthattheclonebindslamininβ1underreducingconditionsaswellasnativeELISAsandthattheaffinityisincreasedbythepresenceofthelamininα1chain.Thusthereissignificantlamininβ1reactivitywithcloneAL-2.

ProductInformation
Format	Purified
Presentation	Purifiedin0.1MTris-Glycine(pH7.4)150mMNaClwith0.05%NaN3.

StorageandShippingInformation
StorageConditions	Maintainat2-8°Cinundilutedaliquotsforupto1yearafterdateofreceipt.

Applications
Application	DetectLaminin-1A&BchainsusingthisAnti-Laminin-1A&BchainsAntibody,crossregion,cloneAL-2validatedforuseinELISA,IF,IH(P),IP&WB.
KeyApplications	ELISA Immunofluorescence Immunohistochemistry(Paraffin) Immunoprecipitation WesternBlotting
ApplicationNotes	Immunofluorescence: Anindependentlaboratory(Schèele,S.,2006)hasverifiedanti-laminincloneAL-2toworkusingimmunofluorescencetechniquesonmousemuscletissue,includingbothtransgenicandwild-typetissues.

BIOLOGicalInformation
Immunogen	LamininisolatedfromEHSmousesarcoma.
Epitope	Nearcrossregion
Clone	AL-2
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rat
Specificity	ReactswithEHSmouselamininA&Bchainsonthelongarmnearthecrossregion.
Isotype	IgG1κ
SpeciesReactivity	Mouse
SpeciesReactivityNote	Reactswithmouse.Otherspecieshavenotbeentested.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_005559.2
GeneSymbol	LAMA1 LAMA
PurificationMethod	ProteinGPurified
UniProtNumber	P25391 P55268
UniProtSummary	FUNCTION:SwissProt:P55268#Bindingtocellsviaahighaffinityreceptor,lamininisthoughttomediatetheattachment,migrationandorganizationofcellsintotissuesduringembryonicdevelopmentbyinteractingwithotherextracellularmatrixcomponents. SIZE:1798aminoacids;195981Da SUBUNIT:Lamininisacomplexglycoprotein,consistingofthreedifferentpolypeptidechains(alpha,beta,gamma),whichareboundtoeachotherbydisulfidebondsintoacross-shapedmoleculecomprisingonelongandthreeshortarmswithglobulesateachend.Beta-2isasubunitoflaminin-3(S-laminin),laminin-4(S-merosin),andlaminin-7(KS-laminin). SUBCELLULARLOCATION:Secreted,extracellularspace.Note=S-lamininisconcentratedinthesynapticcleftoftheneuromuscularjunction. DOMAIN:SwissProt:P55268Thealpha-helicaldomainsIandIIarethoughttointeractwithotherlamininchainstoformacoiledcoilstructure.&DomainsVIandIVareglobular. DISEASE:SwissProt:P55268#DefectsinLAMB2arethecauseofPiersonsyndrome[MIM:609049];alsoknownasmicrocoria-congenitalnephroticsyndrome.Piersonsyndromeischaracterizedbynephroticsyndromewithneonatalonset,diffusemesangialsclerosisandeyeabnormalitieswithmicrocoriaastheleADIngclinicalfeature.Deathusuallyoccurswithinthefirstweeksoflife.Diseaseseveritydependsonthemutationtype:nontruncatingLAMB2mutationsmaydisplayvariablephenotypesrangingfromamildervariantofPiersonsyndrometoisolatedcongenitalnephroticsyndrome.&DefectsinLAMB2areacauseofcongenitalnephroticsyndrome[MIM:609049].Congenitalnephroticsyndromeconstitutesaheterogeneousgroupofconditionshavingincommonthedisruptionofnormalglomerularpermselectivity.CongenitalnephroticsyndromeduetoLAMB2mutationsmaybeassociatedwithocularabnormalities. SIMILARITY:Contains13lamininEGF-likedomains.&Contains1lamininIVtypeBdomain.&Contains1lamininN-terminaldomain.
MolecularWeight	~200kDa

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Millipore/MAB1904 | Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2/MAB1904/100 µg

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