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Millipore/MAB2029 | Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27/MAB2029/100 µg

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貨號: MAB2029

品牌: Millipore

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Description
CatalogueNumber	MAB2029
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-ChondroitinSulfateProteoglycanAntibody,clone9.2.27

ProductInformation
Format	Purified
Presentation	PurifiedfromascitesbyProteinASepharose?chromatography.Purifiedimmunoglobulinin0.02MPBSpH7.6,0.25MNaClcontaining0.1%sodiumazide.

StorageandShippingInformation
StorageConditions	Maintainbetween2and8°Cinundilutedaliquotsforupto6months.

Applications
Application	DetectChondroitinSulfateProteoglycanusingthisAnti-ChondroitinSulfateProteoglycanAntibody,clone9.2.27validatedforuseinFC,IF&IP.
KeyApplications	FlowCytometry Immunofluorescence Immunoprecipitation
ApplicationNotes	Immunofluorescencemicroscopyofcellsinculture(Bumoietal.,1984;Schrappeetal.,1992).Also,LeggJetal(2003)Development130:6049-6063{3%PFAfixedfrozensections}. Immunoelectronmicroscopy(Bumoietal.,1984) Immunoprecipitation:1μg/10E6cells(Bumoietal.,1984;Morganetal.,1981) FACSanalysis:1-2μg/10E6cells FunctionalblockofmelanomacellspreADIng(Morganetal.,1981),gliomacellproliferation3andtumorgrowthinnudemice(Morganetal.,1981;Schrappeetal.,1992). Optimalworkingdilutionsmustbedeterminedbyenduser.

BIOLOGicalInformation
Immunogen	HumanM14melanomacellextractdepletedoffibronectinandboundbylensculinarislectin-Sepharose?(Morganetal.,1981).
Clone	9.2.27
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	Recognizesmaturechondroitinsulfateproteoglycancoreglycoproteinof250kDaaswellasprecursorpolypeptidesof210,220and240kDa(Bumoietal.,1984).Reactswithhumanmelanoma,gliomaandproliferatingbrainendothelialcells.
Isotype	IgG2a
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_001897.4
EntrezGeneSummary	Ahumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreadingonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
GeneSymbol	CSPG4 MSK16 MCSP NG2 MCSPG MEL-CSPG HMW-MAA
UniProtNumber	Q6UVK1
UniProtSummary	FUNCTION:SwissProt:Q6UVK1#Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades. SIZE:2322aminoacids;250497Da SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16. SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity). TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells. PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity). SIMILARITY:SwissProt:Q6UVK1##Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains. MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells.

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Millipore/MAB2029 | Anti-Chondroitin Sulfate Proteoglycan Antibody, clone 9.2.27/MAB2029/100 µg

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