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Millipore/MAB2059 | Anti-Integrin β4 Antibody, clone ASC-8/MAB2059/100 µg

價格: ￥4440.00 市場價: 7400.00

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貨號: MAB2059

品牌: Millipore

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Description
CatalogueNumber	MAB2059
Replaces	05-283
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-Integrinβ4Antibody,cloneASC-8
AlternateNames	CD104 MAB2059Z

ProductInformation
Format	Purified
Presentation	Liquidin0.02MPBpH7.6,0.25MNaClcontaining0.1%sodiumazide.

StorageandShippingInformation
StorageConditions	Maintainat2-8°Cinundilutedaliquotsforupto6months.

Applications
Application	Anti-Integrinβ4Antibody,cloneASC-8isanantibodyagainstIntegrinβ4foruseinFC,IP,IH.
KeyApplications	FlowCytometry Immunoprecipitation Immunohistochemistry AffectsFunction
ApplicationNotes	Immunoprecipitation:ArepresentativelotofthisantibodycloneprecipitatedPAGEbandsof66,76,120,135and200kDa(reduced)or66,110,125,130and190kDa(non-reduced)fromsurface-biotinylatedSCC9cells. Immunohistochemistry:Arepresentativelotofthisantibodyclonewasusedinimmunohistochemistry(acetone-fixedfrozenhumanepithelialtissuesincludingtongue,foreskinandovary.Notforuseonformalin-fixedtissue). FlowCytometry:Arepresentativelotofthisantibodyclonestainedhumansquamouscellcarcinoma(SCC9),ovariancarcinoma(SKOV-3)andumbilicalveinendothelium(HUVEC).StainsRKOorK562cellstransfectedforCD104expression.Doesnotstainmonocytes,neutrophils,lymphocytes,Tcells,Bcellsorplatelets. FunctionalActivityAssay:Arepresentativelotofthisantibodycloneinducedasub-basalsplitatthebasementmembraneinnon-woundedtissue.Inaddition,woundclosurewassignificantlyinhibitedbyASC-8,astheepithelialtongueonlycovered40percentofthewoundareaat120hourspost-wounding.Theseresultsdemonstratethattheβ4adhesion-blockingantibodymayhaveadverseeffectsonnormaltissue(Egles,C.,etal.,2010). Workingdilutionsmustbedeterminedbyenduser.

BIOLOGicalInformation
Immunogen	Humansquamouscellcarcinomacells(SCC9)
Clone	ASC-8
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	Humanbeta4integrin(CD104)
Isotype	IgG1κ
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_000213.3 NM_001005619.1 NM_001005731.1
EntrezGeneSummary	Integrinsareheterodimerscomprisedofalphaandbetasubunits,thatarenoncovalentlyassociatedtransmembraneglycoproteinreceptors.Differentcombinationsofalphaandbetapolypeptidesformcomplexesthatvaryintheirligand-bindingspecificities.Integrinsmediatecell-matrixorcell-celladhesion,andtransducedsignalsthatregulategeneexpressionandcellgrowth.Thisgeneencodestheintegrinbeta4subunit,areceptorforthelaminins.Thissubunittendstoassociatewithalpha6subunitandislikelytoplayapivotalroleinthebiologyofinvasivecarcinoma.Mutationsinthisgeneareassociatedwithepidermolysisbullosawithpyloricatresia.Multiplealternativelysplicedtranscriptvariantsencodingdistinctisoformshavebeenfoundforthisgene.
GeneSymbol	ITGB4 CD104 GP150
UniProtNumber	P16144
UniProtSummary	FUNCTION:SwissProt:P16144#Integrinalpha-6/beta-4isareceptorforlaminin.Itplaysacriticalstructuralroleinthehemidesmosomeofepithelialcells. SIZE:1822aminoacids;202151Da SUBUNIT:Heterodimerofanalphaandabetasubunit.Beta-4associateswithalpha-6. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Integrinalpha-6/beta-4ispredominantlyexpressedbyepithelia.Isoformbeta-4Disalsoexpressedincolonandplacenta.Isoformbeta-4Eisalsoexpressedinepidermis,lung,duodenum,heart,spleenandstomach. DOMAIN:SwissProt:P16144Thefibronectintype-III-likedomainsbindBPAG1andplectinandprobablyalsorecruitBP230. DISEASE:SwissProt:P16144#DefectsinITGB4areacauseofepidermolysisbullosaletaliswithpyloricatresia(EB-PA)[MIM:226730];alsoknownasjunctionalepidermolysisbullosawithpyloricatresia(PA-JEB)oraplasiacutiscongenitawithgastrointestinalatresia.EB-PAischaracterizedbymucocutaneousfragilityandgastrointestinalatresia,whichmostcommonlyaffectsthepylorus.&DefectsinITGB4areacauseofgeneralizedatrophicbenignepidermolysisbullosa(GABEB)[MIM:226650].Thisnonlethalformofjunctionalepidermolysisbullosaischaracterizedbylife-longblisteringoftheskin,associatedwithhairandtoothabnormalities. SIMILARITY:Belongstotheintegrinbetachainfamily.&Contains1Calx-betadomain.&Contains4fibronectintype-IIIdomains.&Contains1VWFAdomain.

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Millipore/MAB2059 | Anti-Integrin β4 Antibody, clone ASC-8/MAB2059/100 µg

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