| Immunogen | AcetylcholinesteraseAChEfromhumanerythrocyte. | 
| Clone | AE-1 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Acetylcholinesterasefromhumanandmonkey. | 
| Isotype | IgG1 | 
| SpeciesReactivity | BovineCanineChickenGuineaPigHumanMonkey
 | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Acetylcholinesterasehydrolyzestheneurotransmitter,acetylcholineatneuromuscularjunctionsandbraincholinergicsynapses,andthusterminatessignaltransmission.Itisalsofoundontheredbloodcellmembranes,whereitconstitutestheYtbloodgroupantigen.Acetylcholinesteraseexistsinmultiplemolecularformswhichpossesssimilarcatalyticproperties,butdifferintheiroligomericassemblyandmodeofcellattachmenttothecellsurface.ItisencodedbythesingleACHEgene,andthestructuraldiversityinthegeneproductsarisesfromalternativemRNAsplicing,andpost-translationalassociationsofcatalyticandstructuralsubunits.Themajorformofacetylcholinesterasefoundinbrain,muscleandothertissuesisthehydrophilicspecies,whichformsdisulfide-linkedoligomerswithcollagenous,orlipid-containingstructuralsubunits.Theother,alternativelysplicedform,expressedprimarilyintheerythroidtissues,differsattheC-terminalend,andcontainsacleavablehydrophobicpeptidewithaGPI-anchorsite.Itassociateswiththemembranesthroughthephosphoinositide(PI)moietiesaddedpost-translationally. | 
| GeneSymbol | ACHEN-ACHEacetylcholinesteraseAChEYTARACHEEC3.1.1.7
 | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P22303#Rapidlyhydrolyzescholinereleasedintothesynapse. SIZE:614aminoacids;67796Da
 SUBUNIT:Homotetramer;composedofdisulfide-linkedhomodimers.InteractswithPRIMA1.TheinteractionwithPRIMA1isrequiredtoanchorittothebasallaminaofcellsandorganizeintotetramers(Bysimilarity).
 SUBCELLULARLOCATION:Celljunction,synapse.Secreted(Bysimilarity).Cellmembrane;Peripheralmembraneprotein(Bysimilarity).&Isoform2:Cellmembrane;Lipid-anchor,GPI-anchor;Extracellularside(Bysimilarity).
 SIMILARITY:SwissProt:P22303##Belongstothetype-Bcarboxylesterase/lipasefamily.
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