| Immunogen | Ratbrainmicrotubule-associatedprotein. | 
| Clone | AA6 | 
| Host | Mouse | 
| Specificity | ReactsspecificallywithMAP1B(MAP5)byimmunoblot.Showsselectivestainingofdendritictreesthroughoutthebrain.Nocross-reactivityobservedtootherMAPsortubulin.
  MonoclonalAnti-MAP1bisimmunospecificforMAP1b(alsoknownasMAP5,MAPIXorMAP1.2;Riedereretal.,1986;Tuckeretal.,1988)asdeterminedbyanimmunoblotassay.Additionofantibodytomicrotubuleproteinsbeforepolymerizationresultsinabnormallyshort(butotherwisemorphologicallynormal)microtubules. | 
| Isotype | IgG1 | 
| SpeciesReactivity | - Bovine
 - Chicken
 - Hamster
 - Mouse
 - Rat
 - Feline
 
  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesaproteinthatbelongstothemicrotubule-associatedproteinfamily.Theproteinsofthisfamilyarethoughttobeinvolvedinmicrotubuleassembly,whichisanessentialstepinneurogenesis.TheproductofthisgeneisaprecursorpolypeptidethatpresumablyundergoesproteolyticprocessingtogeneratethefinalMAP1BheavychainandLC1lightchain.Geneknockoutstudiesofthemousemicrotubule-associatedprotein1Bgenesuggestedanimportantroleindevelopmentandfunctionofthenervoussystem. | 
| GeneSymbol | - MAP1B
 - DKFZp686F1345
 - FUTSCH
 - DKFZp686E1099
 - MAP5
 - FLJ38954
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P46821#ThefunctionofbrainMAPSisessentiallyunknown.PhosphorylatedMAP1Bmayplayaroleinthecytoskeletalchangesthataccompanyneuriteextension.PossIBLyMAP1BBindstoatleasttwotubulinsubunitsinthepolymer,andthisbridgingofsubunitsmightbeinvolvedinnucleatingmicrotubulepolymerizationandinstABIlizingmicrotubules. SIZE:2468aminoacids;270620Da SUBUNIT:3differentlightchains,LC1,LC2andLC3,canassociatewithMAP1AandMAP1Bproteins.LC1interactswiththeamino-terminalregionofMAP1B.InteractswithANP32A(Bysimilarity). DOMAIN:SwissProt:P46821HasahighlybasicregionwithmanycopiesofthesequenceKKEEandKKEI/V,repeatedbutnotatfixedintervals,whichisresponsibleforthebindingofMAP1Btomicrotubules. PTM:LC1isgeneratedfromMAP1Bbyproteolyticprocessing.&PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:BelongstotheMAP1family. |