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Millipore/MAB4092 | Anti-P-Selectin Glycoprotein Ligand-1 Antibody, clone KPL-1/MAB4092/100 µg

價格: ￥3324.00 市場價: 5540.00

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貨號: MAB4092

品牌: Millipore

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Description
CatalogueNumber	MAB4092
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-P-SelectinGlycoproteinLigand-1Antibody,cloneKPL-1
AlternateNames	PSGL-1 CD162
BackgroundInformation	InteractionsbetweenP-selectinandP-selectinglycoproteinligand-1(PSGL-1)mediatetheearliest“rolling”ofleukocytesonthelumenalsurfaceofendothelialcellsatsitesofinflammation.Todate,theprimaryroleofPSGL-1inmediatingtheinteractionbetweenneutrophilsandP-selectinhasbeenwelldocumented.MAB4092completelyblocksrecognitionofPSGL-1byeitherP-selectinorbyL-selectin,butdoesnotaffectleukocyterecognitionofE-selectin.TwocolorflowcytometryofnormalleukocyteshasdemonstratedthatPSGL-1isexpressedonessentiallyallbloodneutrophils,NKcells,bloodcells,Tcells,andmonocytes,butPSGL-1stainsBcellsatsignificantlylowerlevelsthanothercelltypes.VariationintyrosinesulfationduringBcelldifferentiationmayaffectthestABIlityofBcellstointeractwithP-andL-selectin.{Snapp,KRetal1998}.

ProductInformation
Format	Purified
Presentation	PurifiedImmunoglobulin.Liquidin0.02MPBwith0.25MNaCl,pH7.6,0.1%SodiumAzide.

StorageandShippingInformation
StorageConditions	Maintainat2-8°Cinundilutedaliquotsupto12months.

Applications
Application	DetectP-SelectinGlycoproteinLigand-1usingthisAnti-P-SelectinGlycoproteinLigand-1Antibody,cloneKPL-1validatedforuseinFC,IH,IH(P),IP&WB.
KeyApplications	FlowCytometry Immunohistochemistry Immunohistochemistry(Paraffin) Immunoprecipitation WesternBlotting
ApplicationNotes	WesternblotofHL60wholecelllysatespreparedwith1%tritonX-100in150mMNaCl,10mMTris-HCLpH7.6,1mMCa++,1mMMg++,with1mmolaprotinin,PMSF,leupeptin,andpepstatinA{Snapp,KRetal1998}.1:1000 FACS{Snapp,KRetal1998}. Immunoprecipitation:0.5%tritonX-100inTBSwithproteinaseinhibitors;5μg/500μLofwholecelllysate(350-500mg/mLtotalprotein). FunctionalblockingofP-selectin{SnappKRetal1998}. Immunohistochemistry:Freshfrozen,acetonefixedsections Immunohistochemistryinparaffinembeddedtissues:formalinfixed,pretreatmentstandardcitricacidpH6.0,microwavetreatmentisrecommended1:50-1:200 Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	TheantibodyepitopewasmappedtoasitewithinaconsensustyrosinesulfationmotifofPSGL-1,previouslyshowntobeessentialforinteractionwithP-selectin(andnowshowntobeessentialforrecognitionofPSGL-1byL-selectin).
Clone	KPL-1
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	P-selectinglycoproteinligand-1(PSGL-1).TheantibodyepitopewasmappedtoasitewithinaconsensustyrosinesulfationmotifofPSGL-1,previouslyshowntobeessentialforinteractionwithP-selectin(andnowshowntobeessentialforrecognitionofPSGL-1byL-selectin).{SnappKRetal.1998}.ThebindingofKPL-1tohumanPSGL-1onHL-60cellsdoesnotrequiresulfation{Thatte,Aetal2002}.
Isotype	IgG1κ
SpeciesReactivity	Human
SpeciesReactivityNote	KnownnottoreactwithRat,Bovine,Pig,andEquinePSGL-1{Snapp,KRetal1998;Baisse,Betal2007}.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_003006.3
EntrezGeneSummary	SELPLGisthehighaffinitycounter-receptorforP-selectinonmyeloidcellsandstimulatedTlymphocytes.Assuch,itplaysacriticalroleinthetetheringofthesecellstoactivatedplateletsorendotheliaexpressingP-selectin.TheorganizationoftheSELPGgenecloselyresemblesthatofCD43andthehumanplateletglycoproteinGpIb-alphabothofwhichhaveanintroninthe5-prime-noncodingregion,alongsecondexoncontainingthecompletecodingregion,andTATA-lesspromoters.
GeneSymbol	SELPLG CLA PSGL-1 CD162 PSGL1
UniProtNumber	Q14242
UniProtSummary	FUNCTION:SwissProt:Q14242#BindstoP-,E-andL-selectins.Thecalcium-dependenthighaffinityinteractionwithP-selectinmediatesthetetheringandrollingofneutrophilsandT-lymphocytesonendothelialcells. SIZE:412aminoacids;43201Da SUBUNIT:Homodimer;disulfide-linked. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Expressedonneutrophils,monocytesandmostlymphocytes. PTM:Displayscomplex,sialylatedandfucosylatedO-linkedoligosaccharides,atleastsomeofwhichappeartocontainpoly-N-acetyllactosaminewithvaryingdegreesofsubstitution.AlsoN-glycosylated.&SulfatedintheN-terminalregion;sulfationisnecessaryforP-selectinbinding.

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Millipore/MAB4092 | Anti-P-Selectin Glycoprotein Ligand-1 Antibody, clone KPL-1/MAB4092/100 µg

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