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Millipore/MAB4603 | Anti-Caspase 3 Antibody, large subunit & proform, clone 3CSP03/MAB4603/50 µg

價格: ￥3948.00 市場價: 6580.00

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貨號: MAB4603

品牌: Millipore

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Description
CatalogueNumber	MAB4603
Replaces	04-440;04-1088
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-Caspase3Antibody,largesubunit&proform,clone3CSP03
AlternateNames	CPP32

ProductInformation
Format	Purified
Presentation	Liquidin10mMPBS,pH7.4,with0.2%BSAand15mMsodiumazide.

StorageandShippingInformation
StorageConditions	Maintainrefrigeratedat2-8°Cinundilutedaliquotsforupto12months.

Applications
Application	DetectCaspase3usingthisAnti-Caspase3Antibody,largesubunit&proform,clone3CSP03validatedforuseinIP,WB,IH(P).
KeyApplications	Immunoprecipitation WesternBlotting Immunohistochemistry(Paraffin)
ApplicationNotes	Westernblot:1μg/mlfor2hoursatRT. Immunoprecipitation:2μg/mgofproteinlysateImmunohistochemistry(frozenandparaffin):2-4μg/mlfor30minutesatRT.Stainingofformalin-fixedtissuesrequiresboilingtissuesectionsin10mMcitratebuffer,pH6.0,for10-20min.followedbycoolingfor20min.atRT. Optimalworkingdilutionsmustbedeterminedbyenduser.

BIOLOGicalInformation
Immunogen	Recombinantfull-lengthhumancaspase-3protein
Epitope	largesubunit&proform
Clone	3CSP03
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	Recognizesaproteinof32kDa,identifiedastheCaspase-3protein.HighlyspecifictoCaspase-3andshowsnocross-reactionwithothercaspasefamilymembers.Caspase-3isubiquitouslyexpressedandlikeothercaspasesissynthesizedasaninactiveproenzyme.Uponactivation,caspase-3iscleavedgeneratingtwosubunitsof17kDaand12kDarespectively.Caspase-3hasbeenimplicatedintheinductionofapoptosis.Activationofcaspase-3occursinresponsetoavarietyofapoptoticinducers,includingFas-mediatedapoptosis.
Isotype	IgG2a
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_004346.3 NM_032991.2
EntrezGeneSummary	Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Thisproteincleavesandactivatescaspases6,7and9,andtheproteinitselfisprocessedbycaspases8,9and10.Itisthepredominantcaspaseinvolvedinthecleavageofamyloid-beta4Aprecursorprotein,whichisassociatedwithneuronaldeathinAlzheimer"sdisease.Alternativesplicingofthisgeneresultsintwotranscriptvariantsthatencodethesameprotein.
GeneSymbol	CASP3 apopain CASP-3 procaspase3 CPP32B SCA-1 CPP-32 Apopain CPP32 Yama EC3.4.22.56[Contains:Caspase-3subunitp17 Caspase-3subunitp12].
UniProtNumber	P42574
UniProtSummary	FUNCTION:SwissProt:P42574#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Attheonsetofapoptosisitproteolyticallycleavespoly(ADP-ribose)polymerase(PARP)ata"216-Asp--Gly-217"bond.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs)betweenthebasichelix-loop-helixleucinezipperdomainandthemembraneattachmentdomain.Cleavesandactivatescaspase-6,-7and-9.Involvedinthecleavageofhuntingtin. SIZE:277aminoacids;31608Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya17kDa(p17)anda12kDa(p12)subunit. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyexpressedinlung,spleen,heart,liverandkidney.Moderatelevelsinbrainandskeletalmuscle,andlowintestis.Alsofoundinmanycelllines,highestexpressionincellsoftheimmunesystem. PTM:CleavagebygranzymeB,caspase-6,caspase-8andcaspase-10generatesthetwoactivesubunits.Additionalprocessingofthepropeptidesislikelyduetotheautocatalyticactivityoftheactivatedprotease.Activeheterodimersbetweenthesmallsubunitofcaspase-7proteaseandthelargesubunitofcaspase-3alsooccurandviceversa. SIMILARITY:SwissProt:P42574##BelongstothepeptidaseC14family.

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Millipore/MAB4603 | Anti-Caspase 3 Antibody, large subunit & proform, clone 3CSP03/MAB4603/50 µg

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