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Millipore/MAB5284 | Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301/MAB5284/100 &mic

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貨號: MAB5284

品牌: Millipore

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Description
CatalogueNumber	MAB5284
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-ChondroitinSulfateProteoglycanAntibody,Brain(coreprotein),cloneCat-301
AlternateNames	CSPG
BackgroundInformation	Theantigenrecognizedbythisclone,CAT-301isaproteoglycanthatisdevelopmentalyregulated,highmolecularchondroitinsulphateproteoglycanfoundontheextracellularsurfaceofmammalianneurons.ItisexpressedlateindevelopmentandalthoughnodefinitiverolehasbeenidentifiedforCAT-301,itisbelievedtohavearoleinthestABIlisationofsynapticstructure. Thenamederivesfromthenameofthemonoclonalantibodyoriginallyusedtoidentifiedbyitsexpression,whichwasdetectedimmunocytochemicaly DisruptionofthenormalpatternsofneuronalactivityduringthecriticalearlypostnatalperiodbyphysicalorbiochemicalmeansresultsinalargeandirreversIBLereductioninlevelsofCAT-301.Similarinterventioninmatureanimalshasnoeffect CAT-301isrelatedtoaggrecanfromarticularcartilage.TheCAT-301antibodyimmunoreactswithaggrecan,andthechondroitinasetreatedaggrecanandCAT-301bothhaveapparentsizesof550kDa.HoweverCAT-301isnotglycosylatedbykeratansulphate,asaggrecanis.

ProductInformation
Format	Purified
Presentation	Purifiedimmunoglobulin.Liquid.Buffer=0.02MPhosphatebuffer,0.25MNaCl,pH7.6with0.1%sodiumazide.

StorageandShippingInformation
StorageConditions	Maintainat2-8°Cinundilutedaliquotsforupto6months.

Applications
Application	Anti-ChondroitinSulfateProteoglycanAntibody,Brain(coreprotein),cloneCat-301detectslevelofChondroitinSulfateProteoglycan&hasbeenpublished&validatedforuseinIP,WB,IC,IH.
KeyApplications	Immunoprecipitation WesternBlotting Immunocytochemistry Immunohistochemistry
ApplicationNotes	Immunohistochemistry:1:500-1:2,000on4%paraformaldehydefixedfrozentissue. Immunocytochemistry Immunoblot Immunoprecipitation Optimalworkingdilutionsmustbedeterminedbytheenduser.

BIOLOGicalInformation
Immunogen	Felinespinalcordfixedgraymatter.
Epitope	Brain(coreprotein)
Clone	Cat-301
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	Chondroitinsulfateproteoglycan(CSPG),braincoreprotein.
Isotype	IgG1
SpeciesReactivity	GuineaPig Human Hamster Rat Feline Gerbil Primate
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_001135.2 NM_013227.2
EntrezGeneSummary	Thisgeneisamemberoftheaggrecan/versicanproteoglycanfamily.Theencodedproteinisanintegralpartoftheextracellularmatrixincartilagenoustissueanditwithstandscompressionincartilage.Mutationsinthisgenemaybeinvolvedinskeletaldysplasiaandspinaldegeneration.Multiplealternativelysplicedtranscriptvariantsthatencodedifferentproteinisoformshavebeenobservedinthisgene.
GeneSymbol	ACAN MSK16 SEDK CSPCP AGCAN AGC1 CSPG1 CSPGCP
UniProtNumber	P16112
UniProtSummary	FUNCTION:SwissProt:P16112#Thisproteoglycanisamajorcomponentofextracellularmatrixofcartilagenoustissues.Amajorfunctionofthisproteinistoresistcompressionincartilage.ItbindsavidlytohyaluronicacidviaanN-terminalglobularregion. SIZE:2415aminoacids;250193Da SUBUNIT:InteractswithFBLN1(Bysimilarity). SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix(Bysimilarity). TISSUESPECIFICITY:Restrictedtocartilages. DEVELOPMENTALSTAGE:Expressionwasdetectedinchondrocytesthroughoutthedevelopingskeleton. DOMAIN:SwissProt:P16112Twoglobulardomains,G1andG2,comprisetheN-terminusoftheproteoglycan,whileanotherglobularregion,G3,makesuptheC-terminus.G1containsLinkdomainsandthusconsistsofthreedisulfide-bondedloopstructuresdesignatedastheA,B,B"motifs.G2issimilartoG1.Thekeratansulfate(KS)andthechondroitinsulfate(CS)attachmentdomainsliebetweenG2andG3. PTM:Containsmostlychondroitinsulfate,butalsokeratansulfatechains,N-linkedandO-linkedoligosaccharides.Thereleaseofaggrecanfragmentsfromarticularcartilageintothesynovialfluidatallstagesofhumanosteoarthritisistheresultofcleavagebyaggrecanase. DISEASE:SwissProt:P16112#DefectsinAGC1arethecauseofspondyloepiphysealdysplasiatypeKimberley(SEDK)[MIM:608361].Spondyloepiphysealdysplasiasareaheterogeneousgroupofcongenitalchondrodysplasiasthatspecificallyaffectepiphysesandvertebrae.TheautosomaldominantSEDKisassociatedwithprematuredegenerativearthropathy. SIMILARITY:Belongstotheaggrecan/versicanproteoglycanfamily.&Contains1C-typelectindomain.&Contains1EGF-likedomain.&Contains1Ig-likeV-type(immunoglobulin-like)domain.&Contains4Linkdomains.&Contains1Sushi(CCP/SCR)domain.

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Millipore/MAB5284 | Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301/MAB5284/100 &mic

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