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Millipore/MAB5406 | Anti-GAD67 Antibody, clone 1G10.2/MAB5406/100 µg

價格: ￥4440.00 市場價: 7400.00

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貨號: MAB5406

品牌: Millipore

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Description
CatalogueNumber	MAB5406
Replaces	AB5992;AB5862P
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-GAD67Antibody,clone1G10.2
AlternateNames	GlutamateDecarboxylase67kDaIsoform GlutamateDecarboxylase1 Glutamicaciddecarboxylase1
BackgroundInformation	Gutamicaciddecarboxylase(GAD;E.C.4.1.1.15)istheenzymeresponsIBLefortheconversionofglutamicacidtogamma-aminobutyricacid(GABA),themajorinhibitorytransmitterinhigherbrainregions,andputativeparacrinehormoneinpancreaticislets.TwomolecularformsofGAD(65kDaand67kDa,64%aaidentitybetweenforms)arehighlyconservedandbothformsareexpressedintheCNS,pancreaticisletcells,testis,oviductandovary.Theisoformsareregionallydistributedcytoplasmicallyinthebrainsofratsandmice(Sheikh,1999).GAD65isanamphiphilic,membrane-anchoredprotein(585a.a.),encodedonhumanchromosome10,andisresponsibleforvesicularGABAproduction.GAD67iscytoplasmic(594a.a.),encodedonchromosome2,andseemstoberesponsibleforsignificantcytoplasmicGABAproduction.GADexpressionchangesduringneuraldevelopmentinratspinalcord.GAD65isexpressedtransientlyincommissuralaxonsaroundE13butisdownregulatedthenextdaywhileGAD67expressionincreasesmostlyinthesomataofthoseneurons(Phelps,1999).Inmatureratpancreas,GAD65andGAD67appeartobedifferentiallylocalized,GAD65primarilyininsulin-containingbetacellsandGAD67inglucagon-containing(A)cells(Li,1995).GAD67expressionseemstobeparticularlyplasticandcanchangeinresponsetoexperimentalmanipulation(forexampleneuronalstimulationortransection)ordiseaseprogressionandemergentdisorderslikeschizophrenia(Volk,2000).ColocalizationofthetwoGADisoformsalsoshowschangesinGAD65/GAD67distributionscorrelatedwithcertaindiseasestatessuchasIDDMandSMS.

ProductInformation
Format	Purified
Control	SKNSHcelllysate(humanneuroblastoma),mousecerebralcortex.
Presentation	PurifiedmousemonoclonalIgG2ainbuffercontaining0.1%sodiumazide

StorageandShippingInformation
StorageConditions	Stablefor6monthsat2-8oCinundilutedaliquotsfromdateofreceipt.

Applications
Application	ThisAnti-GADAntibody,clone1G10.2isvalidatedforuseinIH,IH(P),WBforthedetectionofGAD67.ThisAntiGADantibodyhasmorethan75productcitations.
KeyApplications	Immunohistochemistry Immunohistochemistry(Paraffin) WesternBlotting
ApplicationNotes	WesternBlot:A1:5,000-1:10,000dilutionwasusedonapreviouslotusingECLonratandmousebrainlysate. Immunohistochemistryon4%paraformaldehydefixedmouseandrattissue:1:1,000-1:5,000.Theantibodyhasalsoworkedwellonhumantissuefixedfor10minutesin4%PFAat4°Cor100%ethanolat+20°Cor100%acetoneat-20°Catdilutionsof1:2,500-1:5,000. ApolyclonaltoGAD67isalsoavailableasAB5992. Optimalworkingdilutionsmustbedeterminedbyenduser.

BIOLOGicalInformation
Immunogen	RecombinantGAD67protein
Clone	1G10.2
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	Reactswiththe67kDaisoformofGlutamateDecarboxylase(GAD67)ofrat,mouseandhumanorigins,otherspeciesnotyettested.NodetectablecrossreactivitywithGAD65byWesternblotonratbrainlysatewhencomparedtoblotprobedwithAB1511thatreactswithbothGAD65&GAD67.
Isotype	IgG2a
SpeciesReactivity	Human Rat Mouse
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_000817.2
EntrezGeneSummary	Thisgeneencodesoneofseveralformsofglutamicaciddecarboxylase,identifiedasamajorautoantigenininsulin-dependentdiabetes.Theenzymeencodedisresponsibleforcatalyzingtheproductionofgamma-aminobutyricacidfromL-glutamicacid.ApathogenicroleforthisenzymehasbeenidentifiedinthehumanpancreassinceithasbeenidentifiedasanautoantigenandanautoreactiveTcelltargetininsulin-dependentdiabetes.Thisgenemayalsoplayaroleinthestiffmansyndrome.Deficiencyinthisenzymehasbeenshowntoleadtopyridoxinedependencywithseizures.Alternativesplicingofthisgeneresultsintwoproducts,thepredominant67-kDformandaless-frequent25-kDform.
GeneSymbol	GAD1 SCP GAD-67 FLJ45882 GAD67 GAD EC4.1.1.15
PurificationMethod	ProteinAPurfied
UniProtNumber	Q99259
UniProtSummary	FUNCTION:SwissProt:Q99259#CatalyzestheproductionofGABA. COFACTOR:Pyridoxalphosphate. SIZE:594aminoacids;66897Da SUBUNIT:Homodimer. TISSUESPECIFICITY:GAD67isexpressedintheCNS,pancreaticisletcells,testis,oviductandovary. DISEASE:SwissProt:Q99259#DefectsinGAD1arethecauseofautosomalrecessivesymmetricspasticcerebralpalsy(SCP)[MIM:603513].Cerebralpalsy(CP)isanheterogeneousgroupofneurologicaldisordersofmovementand/orposture,withanestimatedincidenceof1in250to1"000livebirths,makingCPonethecommonestcongenitaldisABIlities.Non-progressiveformsofsymmetrical,spasticCPhavebeenidentified,whichshowaMendelianautosomalrecessivepatternofinheritance.Patientspresentdevelopmentaldelay,mentalretardationandsometimesepilepsyaspartofthephenotype. SIMILARITY:SwissProt:Q99259##BelongstothegroupIIdecarboxylasefamily.
MolecularWeight	67kDa

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Millipore/MAB5406 | Anti-GAD67 Antibody, clone 1G10.2/MAB5406/100 µg

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