| Immunogen | RecombinantproteincorrespondingtohumanNkx2.2. |
| Clone | 1C11 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Isotype | IgG2aκ |
| SpeciesReactivity | |
| SpeciesReactivityNote | DemonstratedtoreactwithMouse. PredictedtoreactwithHumanbasedonimmunogendesign. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgenecontainsahomeoboxdomainandmaybeinvolvedinthemorphogenesisofthecentralnervoussystem.Thisgeneisfoundonchromosome20nearNKX2-4,andthesetwogenesappeartobeduplicatedonchromosome14intheformofTITF1andNKX2-8.Theencodedproteinislikelytobeanucleartranscriptionfactor.[providedbyRefSeq,Jul2008]. |
| GeneSymbol | |
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Actsasatranscriptionalactivator.RequiredforthemaintenanceofNEUROD1expressioninthehoromone-producingendocrinecellsofthepancreas.Maybeinvolvedinspecifyingdiencephalicneuromericboundaries,andincontrollingtheexpressionofgenesthatplayaroleinaxonalguidance.AssociateswithchromatinattheNEUROD1promoterregion.BindstoasubsetofconsensuselementswithintheNEUROD1promoter(Bysimilarity).
SUBUNITSTRUCTURE:InteractswithOLIG2(Bysimilarity).
SUBCELLULARLOCATION:Nucleus(Bysimilarity).
DOMAIN:ThehomeodomainisessentialforinteractionwithOLIG2(Bysimilarity).
SEQUENCESIMILARITIES:BelongstotheNK-2homeoboxfamily.
Contains1homeoboxDNA-bindingdomain. |
| MolecularWeight | ~37kDaobserved. Uncharacterizedbandsmayappearat~25kDaand~300kDainsomelysates. |