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Millipore/MABE15 | Anti-Histone H2B Antibody, clone EP957Y, rabbit monoclonal/MABE15/100 µL

價格: ￥3204.00 市場價: 5340.00

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貨號: MABE15

品牌: Millipore

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Description
CatalogueNumber	MABE15
Description	Anti-HistoneH2BAntibody,cloneEP957Y,rabbitmonoclonal
AlternateNames	histonecluster2,H2be histone2,H2be H2Bhistonefamily,memberQ HistoneH2B.q HistoneH2B-GL105 histoneH2Btype2-E
BackgroundInformation	Changesinchromatinstructureplayalargeroleintheregulationoftranscriptionineukaryotes(1).Thenucleosomeistheprimarybuildingblockofchromatin,andismadeupoffourcorehistoneproteins(H2A,H2B,H3andH4)(2).Acetylationofcorehistonesregulatesgeneexpression(2).HistoneH2Bisprimarilyacetylatedatlysines5,12,15,and20(3).UbiquitylationofHistoneH2Batlysine123byRad6hasbeenimplicatedintranscriptionalactivationandlysinemethylationonhistoneH3(4).HistoneH2BphosphorylationatSer10(foryeast)andSer14(formammaliancells)hasbeenlinkedtoregulationofapoptosisandmeiosis(5).

ProductInformation
Format	Unpurified
Control	A431celllysate
Presentation	Rabbitmonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaCl,40%Glycerol,0.01%sodiumazideand0.05%BSA.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	PleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
KeyApplications	WesternBlotting Immunohistochemistry(Paraffin) Immunocytochemistry Immunoprecipitation
ApplicationNotes	ImmunohistochemistryAnalysis:A1:250–1:500dilutionfromapreviouslotdetectedHistoneH2Binhumanbreastcarcinoma. ImmunoprecipitationAnalysis:A1:30dilutionfromapreviouslotdetectedHistoneH2BinIP. ImmunocytochemistryAnalysis:A1:50–1:100dilutionfromapreviouslotdetectedHistoneH2BinHeLacells.

BIOLOGicalInformation
Immunogen	SyntheticpeptidecorrespondingtohumanHistoneH2B.
Clone	EP957Y
Host	Rabbit
Specificity	ThisantibodyrecognizesHistoneH2B.
Isotype	IgG
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Proventoreactwithhuman,mouse,andrat.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_001019770.1
GeneSymbol	H2B.1 H2B/q H2BFQ H2B MGC119804 MGC129733 H2BGL105 GL105 H2BQ MGC129734 MGC119802
PurificationMethod	Unpurified
UniProtNumber	Q16778
UniProtSummary	FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. Hasbroadantibacterialactivity.Maycontributetotheformationofthefunctionalantimicrobialbarrierofthecolonicepithelium,andtothebactericidalactivityofamnioticfluid. SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus.Chromosome. PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII. PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination. SEQUENCESIMILARITIES:BelongstothehistoneH2Bfamily.
MolecularWeight	~14kDaobserved

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Millipore/MABE15 | Anti-Histone H2B Antibody, clone EP957Y, rabbit monoclonal/MABE15/100 µL

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