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Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL

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貨號: MABE16

品牌: Millipore

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Description
CatalogueNumber	MABE16
Description	Anti-phosphoSir2/SIRT1(Ser47)Antibody,cloneEPR2849Y,rabbitmonoclonal
AlternateNames	SIR2-likeprotein1 sirtuin(silentmatingtypeinformationregulation2homolog)1(S.cerevisiae) sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae,homolog)1
BackgroundInformation	TheS.cerevisiaesilentinformationregulator2(Sir2)proteinisanNAD+-dependenthistonedeacetylase(HDACs)thatplaysacriticalroleintranscriptionalsilencing,genomestABIlity,andlongevity(1-2).PartoftheSirtuinfamily(Sir2,Sir3,Sir3),yeastSir2isthefoundingmemberofClassIIIHDACs.AhumanhomologueofSir2,SIRT1,regulatestheactivityofthep53tumorsuppressorandinhibitsapoptosis(3-4).

ProductInformation
Format	Unpurified
Control	LamBDaphosphatase(LP)-treatedanduntreated293celllysates.
Presentation	Rabbitmonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	UseAnti-phosphoSir2/SIRT1(Ser47)Antibody,cloneEPR2849Y(RabbitMonoclonalAntibody)validatedinWB,IHC,ICCtodetectphosphoSir2/SIRT1(Ser47)alsoknownasSIR2-likeprotein1orsirtuin1.
KeyApplications	WesternBlotting Immunohistochemistry Immunocytochemistry
ApplicationNotes	ImmunohistochemistryAnalysis:A1:250–1:500dilutionfromapreviouslotdetectedSir2/SIRT1inIH. ImmunocytochemistryAnalysis:A1:100–1:250dilutionfromapreviouslotdetectedSir2/SIRT1inIC.

BIOLOGicalInformation
Immunogen	Phospho-specificpeptidecorrespondingtohumanSir2/SIRT1atSer47.
Epitope	Ser47
Clone	EPR2849Y
Host	Rabbit
Specificity	ThisantibodydetectsSir2/SIRT1phosphorylatedonSer47.
Isotype	IgG
SpeciesReactivity	Human
SpeciesReactivityNote	Proventoreactwithhuman.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_036370.2
GeneSymbol	sirtuin1 SIR2L1 hSIR2 hSIRT1
Modifications	Phosphorylation
PurificationMethod	Unpurified
UniProtNumber	Q96EB6
UniProtSummary	FUNCTION:NAD-dependentproteindeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Deacetylates"Lys-382"ofp53/TP53andimpairsitsabilitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD+/NADH,whichisessentialinskeletalmusclecelldifferentiation.Deacetylates"Lys-16"ofhistoneH4(invitro).ComponentoftheeNoSC(energy-dependentnucleolarsilencing)complex,acomplexthatmediatessilencingofrDNAinresponsetointracellularenergystatusandactsbyrecruitinghistone-modifyingenzymes.TheeNoSCcomplexisabletosensetheenergystatusofcell:uponglucosestarvation,elevationofNAD+/NADP+ratioactivatesSIRT1,leADIngtohistoneH3deacetylationfollowedbydimethylationofH3at"Lys-9"(H3K9me2)bySUV39H1andtheformationofsilentchromatinintherDNAlocus.IncaseofHIV-1infection,interactswithanddeacetylatestheviralTatprotein. CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein. COFACTOR:Binds1zincionpersubunitBysimilarity. ENZYMEREGULATION:Inhibitedbynicotinamide.Activatedbyresveratrol(3,5,4"-trihydroxy-trans-stilbene),butein(3,4,2",4"-tetrahydroxychalcone),piceatannol(3,5,3",4"-tetrahydroxy-trans-stilbene),Isoliquiritigenin(4,2",4"-trihydroxychalcone),fisetin(3,7,3",4"-tetrahydroxyflavone)andquercetin(3,5,7,3",4"-pentahydroxyflavone).RPS19BP1/AROSactsasapositiveregulatorofdeacetylationactivity.NegativelyregulatedbyKIAA1967/DBC1. SUBUNITSTRUCTURE:InteractswithTAF1B.FoundinacomplexwithPCAFandMYOD1Bysimilarity.ComponentoftheeNoSCcomplex,composedofSIRT1,SUV39H1andRRP8.InteractswithMLLT7/FOXO4,HES1,HEY2,p53/TP53andPML.InteractswithRPS19BP1/AROS.InteractswithKIAA1967/DBC1(viaN-terminus). SUBCELLULARLOCATION:Nucleus?PMLbody.Note:RecruitedtothenuclearbodiesviaitsinteractionwithPML. TISSUESPECIFICITY:Widelyexpressed. MISCELLANEOUS:Redwine,whichcontainsresveratrol,mayparticipateinactivationofsirtuinproteins,andmaythereforeparticipateinanextendedLifespanasithasbeenobservedinyeast. SEQUENCESIMILARITIES:Belongstothesirtuinfamily. Contains1deacetylasesirtuin-typedomain. SEQUENCECAUTIONS:ThesequenceAAH12499.1differsfromthatshown.Reason:Erroneousinitiation.
MolecularWeight	~110kDaobserved

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Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL

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