當前位置： Millipore >>> Millipore/MABS191 | Anti-phospho-VEGFR2 (Tyr1212) Antibody, clone 12A10.1/MABS191/100 µg

Millipore/MABS191 | Anti-phospho-VEGFR2 (Tyr1212) Antibody, clone 12A10.1/MABS191/100 µg

價格: 試用市場價: 0.00

打印產品信息

貨號: MABS191

品牌: Millipore

規格

默認

數量

庫存(0)

特別提示

代購產品：無質量問題不接受退換貨，下單前請仔細核對信息。
下單后請及時聯系客服核對商品價格，訂單生效后再付款。

立即申請

收藏商品

資深產品顧問

咨詢顧問

全國免費服務熱線

4000-520-616

自營商城一站式服務
廠家直采剔除溢價
品質甄選正品保證
嚴控流程只做188精品
極速物流如約送貨

詳情
使用說明
常見問題

Description
CatalogueNumber	MABS191
Description	Anti-phospho-VEGFR2(Tyr1212)Antibody,clone12A10.1
AlternateNames	Vascularendothelialgrowthfactorreceptor2 VEGFR-2 Fetalliverkinase1 FLK-1 Kinaseinsertdomainreceptor KDR Protein-tyrosinekinasereceptorflk-1 CD309
BackgroundInformation	KDR/Flk-1/VEGFR-2isaputativereceptorproteintyrosinekinaseexpressedinendothelialcellsofthedevelopingembryo.Vascularendothelialgrowthfactor(VEGF)andVEGFR2havebeenimplicatedasthekeyendothelialcell-specificfactorsignalingpathwayrequiredforpathologicalangiogenesis,includingtumorneovascularization.InhibitionoftheVEGFtyrosinekinasesignalingpathwayblocksnewbloodvesselformationingrowingtumors,leADIngtostasisorregressionoftumorgrowth.

ProductInformation
Format	Purified
Control	UntreatedandColony-stimulatingfactor(CSF)treatedPorcineAorticEndothelial(PAE)celllysatesexpressingVEGFR2.
Presentation	PurifiedmousemonoclonalIgMκinbuffercontainingPBSwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	ThisAnti-phospho-VEGFR2(Tyr1212)Antibody,clone12A10.1isvalidatedforuseinWBforthedetectionofphospho-VEGFR2(Tyr1212).
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingtohumanVEGFR2phosphorylatedatTyr1212.
Epitope	PhosphorylatedTyr1212
Clone	12A10.1
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	ThisantibodyrecognizesVEGFR2phosphorylatedatTyr1212.
Isotype	IgMκ
SpeciesReactivity	Pig Human
SpeciesReactivityNote	DemonstratedtoreactwithPorcine.PredictedtoreactwithHumanbasedon100%sequencehomology.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_002244
EntrezGeneSummary	Vascularendothelialgrowthfactor(VEGF)isamajorgrowthfactorforendothelialcells.ThisgeneencodesoneofthetworeceptorsoftheVEGF.Thisreceptor,knownaskinaseinsertdomainreceptor,isatypeIIIreceptortyrosinekinase.ItfunctionsasthemainmediatorofVEGF-inducedendothelialproliferation,survival,migration,tubularmorphogenesisandsprouting.Thesignallingandtraffickingofthisreceptorareregulatedbymultiplefactors,includingRabGTPase,P2Ypurinenucleotidereceptor,integrinalphaVbeta3,T-cellproteintyrosinephosphatase,etc..Mutationsofthisgeneareimplicatedininfantilecapillaryhemangiomas.
GeneSymbol	KDR FLK1 VEGFR2
Modifications	Phosphorylation
PurificationMethod	Purifiedionexchangechromatography
UniProtNumber	P35968
UniProtSummary	FUNCTION:Tyrosine-proteinkinasethatactsasacell-surfacereceptorforVEGFA,VEGFCandVEGFD.Playsanessentialroleintheregulationofangiogenesis,vasculardevelopment,vascularpermeABIlity,andembryonichaematopoiesis.Promotesproliferation,survival,migrationanddifferentiationofendothelialcells.PromotesreorganizationoftheactinCytoskeleton.Isoformslackingatransmembranedomain,suchasisoform2andisoform3,mayfunctionasdecoyreceptorsforVEGFA,VEGFCand/orVEGFD.Isoform2playsanimportantroleasnegativeregulatorofVEGFA-andVEGFC-mediatedlymphangiogenesisbylimitingtheamountoffreeVEGFAand/orVEGFCandpreventingtheirbindingtoFLT4.ModulatesFLT1andFLT4signalingbyformingheterodimers.Bindingofvasculargrowthfactorstoisoform1leadstotheactivationofseveralsignalingcascades.ActivationofPLCG1leadstotheproductionofthecellularsignalingmoleculesdiacylglycerolandinositol-1,4,5-trisphosphateandtheactivationofproteinkinaseC.MediatesactivationofMAPK1/ERK2,MAPK3/ERK1andtheMAPkinasesignalingpathway,aswellasoftheAKT1signalingpathway.MediatesphosphorylationofPIK3R1,theregulatorysubunitofphosphatidylinositol3-kinase,reorganizationoftheactincytoskeletonandactivationofPTK2/FAK1.RequiredforVEGFA-mediatedinductionofNOS2andNOS3,leadingtotheproductionofthesignalingmoleculenitricoxide(NO)byendothelialcells.PhosphorylatesPLCG1.PromotesphosphorylationofFYN,NCK1,NOS3,PIK3R1,PTK2/FAKandSRC. CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. ENZYMEREGULATION:Presentinaninactiveconformationintheabsenceofboundligand.BindingofVEGFA,VEGFCorVEGFDleadstodimerizationandactivationbyautophosphorylationontyrosineresidues.InhibitedbythesmallmoleculePTKinhibitorSU5614((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one). SUBUNITSTRUCTURE:InteractswithMYOF.InteractswithVEGFA,VEGFCandVEGFD.MonomerintheabsenceofboundVEGFA,VEGFCorVEGFD.HomodimerinthepresenceofbounddimericVEGFA,VEGFCorVEGFD.CanalsoformheterodimerswithFLT1andFLT4.Interacts(tyrosinephosphorylated)withFYN,NCK1,PLCG1andSHB.InteractswithHIV-1Tat.InteractswithCBL.InteractswithSH2D2A/TSADandGRB2. SUBCELLULARLOCATION:Isoform1:Cellmembrane;Single-passtypeImembraneprotein.Cytoplasm.Nucleus.Cytoplasmicvesicle.Earlyendosome.Note:Detectedoncaveolae-enrichedlipidraftsatthecellsurface.Isrecycledfromtheplasmamembranetoendosomesandbackagain.PhosphorylationtriggeredbyVEGFAbindingpromotesinternalizationandsubsequentdegradation.VEGFAbindingtriggersinternalizationandtranslocationtothenucleus.Isoforms2and3aresecreted. TISSUESPECIFICITY:Detectedincornea(atproteinlevel).Widelyexpressed.
MolecularWeight	~230kDaobserved

PhysicochemicalInformation

Dimensions

MaterialsInformation

MaterialsInformation

售后保障

螞蟻淘生物188，秉承螞蟻淘一貫的嚴謹態度，由螞蟻淘公司專業人員負責品控、采購、物流、銷售、售后，保障正品優質。以“快速好省，為科研提供好產品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產品帶給科研！? 力求給你最優質的商品。

Q：生物188產品正品保障嗎？
A：生物188質量把控人員具有十年的從業經驗，在業界享有良好的口碑；自營商城，直接從廠家采購，自己的團隊負責國際物流和清關，中間沒有第三方，所有流程嚴格把控，100%保證正品，假一罰十。

Q：下單后可以修改訂單嗎？
A：下單后的商品付款之前可以修改；訂單付款成功，需要聯系我們客服進行修改；客服電話：4000-520-616

Q：可以開發票嗎？
A：本網站所售商品都是正規清關，均開具16%正規發票，發票金額含配送費金額，另有說明的除外。

Q：商品幾天可以發貨？
A：生物188商品，全部現貨銷售，付款后即可發貨,一般一周內送達！

Q：如何聯系商家？
A：有任何問題夠可以電話咨詢我們，全國24小時免費服務熱線：4000-520-616 或聯系我們的在線客服QQ：1570468124

Q：收到的商品少了/發錯了怎么辦？
A：同個訂單購買多個商品可能會分為一個以上包裹發出，可能不會同時送達，建議查看訂單詳情是否是部分發貨狀態；如未收到，可聯系在線客服或者致電4000-520-616。

Q：退換貨/維修需要多長時間？
A：一般情況下，退貨處理周期為客戶收到產品一個月內（以快遞公司顯示簽收時間為準），包裝規格、數量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內申請退換貨；特殊商品以合同條款為準。

24小時熱銷榜

Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
￥830.00
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
￥830.00
Qubit? dsDNA BR Assay Kit Q32853現貨
￥2000.00
Parafilm M封口膜/PM996/4x125/整箱
￥1296.00

Millipore/MABS191 | Anti-phospho-VEGFR2 (Tyr1212) Antibody, clone 12A10.1/MABS191/100 µg

客戶服務

何為188

關注188微信公眾號