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Millipore/MABS77 | Anti-GSK-3 alpha/beta Antibody, clone 12B11.1/MABS77/100 µL

價格: ￥3948.00 市場價: 6580.00

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貨號: MABS77

品牌: Millipore

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Description
CatalogueNumber	MABS77
Replaces	04-361
Description	Anti-GSK-3alpha/betaAntibody,clone12B11.1
AlternateNames	Glycogensynthasekinase-3alpha GSK-3alpha Serine/threonine-proteinkinaseGSK3A
BackgroundInformation	Glycogensynthase-3alpha(GSK-3alpha)isaubiquitousconstitutively-activemultifunctionalkinase.GSK-3alphaphosphorylatesserineandthreonineresiduesonitstargetsubstrates,mostofwhichare“primed”orprephosphorylated.ItismostwidelyresearchedforitsinteractionwithglycogensynthasewhichisdeactivatedafterphosphorylationbyGSK-3alpha;thisactivityblocksthesynthesisofglycogenandplaysanimportantroleintheregulationofglycogen.GSK-3alphaisalsoinvolvedintheWnt/β-catenin,Notch,andHedgehogsignalingpathwaysandaffectsawiderangeofcellularprocessesincludingcell-cycleregulation,transcription,andapoptosis.GSK-3alphaalsophosphorylatestauproteinsandmaycontributetothegenerationofAPP-derivedamyloidplaqueswhichareinvolvedinthepathogenesisofAlzheimer’sdisease.GSK-3alphaisalsoinvestigatedforitsroleintype2diabetes,andcancer.

ProductInformation
Format	Purified
Control	Jurkatcelllysate
Presentation	PurifiedmousemonoclonalIgMκinbuffercontainingPBSwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	ThisAnti-GSK-3alpha/betaAntibody,clone12B11.1isvalidatedforuseinWesternBlotting,ICCforthedetectionofGSK-3alpha/beta.
KeyApplications	WesternBlotting Immunocytochemistry
ApplicationNotes	ImmunocytochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedGSK-3alpha/betainHeLaandA431cells.

BIOLOGicalInformation
Immunogen	Ovalbumin-conjugatedlinearpeptidecorrespondingtohumanGSK-3alpha/beta.
Clone	12B11.1
Host	Mouse
Isotype	IgMκ
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_063937
EntrezGeneSummary	ThisgeneencodesamultifunctionalSer/Thrproteinkinasethatisimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthase,andtranscriptionfactors,suchasJUN.ItalsoplaysaroleintheWNTandPI3Ksignalingpathways,aswellasregulatestheproductionofbeta-amyloidpeptidesassociatedwithAlzheimer"sdisease.[providedbyRefSeq,Oct2011].
GeneSymbol	GSK3A GSK-3alpha/beta
PurificationMethod	PurifiedbyIon-ExchangeChromatography
UniProtNumber	P49840
UniProtSummary	FUNCTION:Constitutivelyactiveproteinkinasethatactsasanegativeregulatorinthehormonalcontrolofglucosehomeostasis,Wntsignalingandregulationoftransctiptionfactorsandmicrotubules,byphosphorylatingandinactivatingglycogensynthase(GYS1orGYS2),CTNNB1/beta-catenin,APCandAXIN1.Requiresprimedphosphorylationofthemajorityofitssubstrates.ContributestoinsulinregulationofglycogensynthesisbyphosphorylatingandinhibitingGYS1activityandhenceglycogensynthesis.Regulatesglycogenmetabolisminliver,butnotinmuscle.Mayalsomediatethedevelopmentofinsulinresistancebyregulatingactivationoftranscriptionfactors.InWntsignaling,regulatesthelevelandtranscriptionalactivityofnuclearCTNNB1/beta-catenin.Facilitatesamyloidprecursorprotein(APP)processingandthegenerationofAPP-derivedamyloidplaquesfoundinAlzheimerdisease.Maybeinvolvedintheregulationofreplicationinpancreaticbeta-cells.Isnecessaryfortheestablishmentofneuronalpolarityandaxonoutgrowth. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. ATP+aprotein=ADP+aphosphoprotein. ENZYMEREGULATION:ActivatedbyphosphorylationatTyr-279.Inresponsetoinsulin,inhibitedbyphosphorylationatSer-21byPKB/AKT1;phosphorylationatthissitecausesaconformationalchange,preventingaccessofsubstratestotheactivesite.Inhibitedbylithium. SUBUNITSTRUCTURE:Monomer.InteractswithARRB2(Bysimilarity).InteractswithAXIN1andCTNNB1/beta-catenin. PTM:PhosphorylatedbyAKT1atSer-21:uponinsulin-mediatedsignaling,theactivatedPKB/AKT1proteinkinasephosphorylatesanddesactivatesGSK3A,resultinginthedephosphorylationandactivationofGYS1.ActivatedbyphosphorylationatTyr-279. MISCELLANEOUS:HigherexpressionandactivityofGSK3Aarefoundintheskeletalmuscle(vastuslateralis)ofpatientswithtype2diabetes(Ref.5).SeveralpotentGSK3(GSK3AandGSK3B)inhibitorshavebeenidentifiedandcharacterizedinpreclinicalmodelsfortreatmentsoftype2diabetes(Ref.17). SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily. Contains1proteinkinasedomain.
MolecularWeight	~46/51kDaobserved

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Millipore/MABS77 | Anti-GSK-3 alpha/beta Antibody, clone 12B11.1/MABS77/100 µL

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